Notice: Images are for illustration only and may not reflect the exact product you receive. Brand-name medications may look different depending on their country of origin—Canadian versions, for example, often include a "PR" symbol on the packaging. Rest assured, the medication, dosage, and active ingredients will be exactly as prescribed. Canada Pharmacy Store is committed to your health and safety, and we work only with licensed pharmacies to ensure you receive trusted, high-quality medication every time.
Description
General Medication Fact Sheet for Tacrolimus
| Field | Information |
|---|---|
| Generic Name | Tacrolimus |
| Brand Name Versions | Prograf, Astagraf XL, Envarsus XR |
| Boxed/Label Warning | Increased risk of serious infections and malignancies (lymphoma and skin cancer). |
| Purpose | Immunosuppressant used to prevent organ rejection after transplantation. Also used to treat atopic dermatitis (eczema). |
| Mechanism of Action | Inhibits T-lymphocyte activation by binding to an intracellular protein (FKBP12) and inhibiting calcineurin. |
| Dosage Forms | Oral capsules, extended-release capsules, oral granules, intravenous solution |
| Available Strengths | Capsules: 0.5 mg, 1 mg, 5 mg; Extended-release capsules: 0.5 mg, 1 mg, 3 mg, 5 mg |
| Dosage Frequency | Usually twice daily (Prograf) or once daily (Astagraf XL, Envarsus XR), depending on the formulation. |
| Common Side Effects | Tremor, headache, diarrhea, nausea, high blood pressure, kidney problems. |
| Serious Side Effects | Infections, lymphoma, skin cancer, kidney damage, seizures, high blood sugar, nerve damage. |
| Drug Interactions | Many drugs can interact with tacrolimus, including antifungals (e.g., ketoconazole), antibiotics (e.g., erythromycin), calcium channel blockers (e.g., verapamil), and grapefruit juice. |
| Important Notes | Regular blood tests are required to monitor tacrolimus levels and kidney function. Avoid grapefruit and grapefruit juice. Protect skin from sun exposure due to increased risk of skin cancer. |
| Storage | Store at room temperature away from moisture and light. |
| Missed Dose | Take as soon as you remember, unless it is almost time for your next dose. Do not double the dose. Consult your doctor for specific instructions. |
| Alternatives | Cyclosporine, Sirolimus, Mycophenolate Mofetil, Azathioprine |
Tacrolimus Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Cyclosporine (Neoral, Gengraf, Sandimmune) | Inhibits T-lymphocyte activation by binding to cyclophilin and inhibiting calcineurin. | Similar mechanism to tacrolimus, but may have different side effect profiles. |
| Sirolimus (Rapamune) | Inhibits T-lymphocyte proliferation by binding to FKBP12 and inhibiting mTOR. | Works on a different pathway than tacrolimus and Cyclosporine. |
| Mycophenolate Mofetil (CellCept) | Inhibits purine synthesis, suppressing T- and B-lymphocyte proliferation. | Often used in combination with tacrolimus or Cyclosporine. |
| Azathioprine (Imuran, Azasan) | Inhibits purine synthesis, suppressing T- and B-lymphocyte proliferation. | An older immunosuppressant, less commonly used now. |
Tacrolimus Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Tremor | Infections (bacterial, viral, fungal) |
| Headache | Lymphoma |
| Diarrhea | Skin cancer |
| Nausea | Kidney damage |
| High blood pressure | Seizures |
| Kidney problems | High blood sugar (diabetes) |
| Insomnia | Nerve damage |
Tacrolimus Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Kidney Transplant | 0.1-0.2 mg/kg/day (Prograf) in two divided doses; adjust based on trough levels | Adjust based on trough levels and clinical response. | Administer consistently with or without food. |
| Liver Transplant | 0.1-0.15 mg/kg/day (Prograf) in two divided doses; adjust based on trough levels | Adjust based on trough levels and clinical response. | Administer consistently with or without food. |
| Heart Transplant | 0.03-0.075 mg/kg/day (Prograf) in two divided doses; adjust based on trough levels | Adjust based on trough levels and clinical response. | Administer consistently with or without food. |
| Atopic Dermatitis (Eczema) – Topical | Apply a thin layer of 0.03% or 0.1% ointment to affected areas twice daily. | Continue application as directed by your healthcare provider. | Do not use on large areas of the body. |
Why Americans Buy Haloperidol from Canada Pharmacy Store?
Why Americans Buy Tacrolimus from Canada Pharmacy Store?
Americans have trouble affording Tacrolimus due to numerous factors—but at Canada Pharmacy Store, we offer a safe, affordable alternative. That’s why thousands of Americans trust us to fill their prescriptions with real savings and real service.
Big Savings on U.S. Medications
Our customers save up to 80% on their Tacrolimus prescriptions compared to U.S. pharmacy prices by ordering through licensed Canadian and international pharmacies.
Free Prescription Transfers
We make it easy! Our pharmacy team can transfer your Tacrolimus prescriptions directly from your doctor or local pharmacy – completely free of charge.
Direct Access to Experts
Our licensed pharmacists are available to support you, answer your questions, and help ensure you’re confident in your treatment.
Referral Discounts
Spread the word—when you refer friends or family, you both save. It’s our way of saying thanks.
Discreet U.S. Shipping
All orders are packaged discreetly and shipped securely to your U.S. address, with your privacy and safety as top priorities.
Trusted by Americans Nationwide
With years of experience and verified medication sources, we’ve become a go-to solution for Americans looking to cut costs without compromising care.
How to Order Haloperidol Online
How to Order Tacrolimus Online
Step 1
Select Your Prescribed Tacrolimus Dosage
Choose the strength and quantity as directed by your healthcare provider and add it to your cart.
Step 2
Proceed Through Secure Checkout
Follow the steps to complete your order and provide necessary shipping and payment details.
Step 3
Upload Your Tacrolimus Prescription
Submit a prescription from a licensed U.S. healthcare provider that matches your order.
At Canada Pharmacy Store, patient safety comes first. We strictly comply with prescription regulations and do not ship any medication without a valid, verifiable prescription. Orders may be declined if a prescription appears falsified or altered in any way. We take these precautions to protect your health and ensure lawful, responsible practices.
Guarantee
Our Guarantee When You Buy Tacrolimus Through Canada Pharmacy Store
At Canada Pharmacy Store, your safety and satisfaction are our top priorities. We supply only authentic, high-quality medications by working exclusively with licensed Canadian pharmacies and trusted international partners. Every order is filled in accordance with strict regulatory standards and includes medication that’s fully approved by Health Canada or other recognized health authorities such as the MHRA (UK), HSA (Singapore), and the Pharmacy Board of Mauritius.
The Tacrolimus you receive is the same active medication as what’s available in the U.S.—the only difference is the packaging, which reflects its country of origin. Our licensed healthcare professionals review each order carefully to ensure it matches your prescription exactly.
To get Tacrolimus at a lower price, simply place your order above or give us a call at 1-888-903-2240
Viewers Also Liked
