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General Medication Fact Sheet for Tamoxifen
| Field | Information |
|---|---|
| Generic Name | Tamoxifen |
| Brand Name Versions | Nolvadex, Soltamox |
| Boxed/Label Warning | Tamoxifen increases the risk of uterine cancer, stroke, and pulmonary embolism. Discuss the risks and benefits with your doctor. |
| Purpose | Treats and prevents breast cancer |
| Mechanism of Action | Selective estrogen receptor modulator (SERM) that blocks estrogen’s effects in breast tissue |
| Dosage Forms | Oral tablets, Oral solution |
| Available Strengths | 10 mg, 20 mg |
| Dosage Frequency | Typically once or twice daily, or as directed by a healthcare provider |
| Common Side Effects | Hot flashes, vaginal discharge, mood swings, fatigue |
| Serious Side Effects | Blood clots, uterine cancer, stroke, cataracts |
| Drug Interactions | Warfarin, certain antidepressants (SSRIs), aromatase inhibitors |
| Important Notes | Regular check-ups and gynecological exams are essential while taking this medication. Not for use during pregnancy. |
| Storage | Store at room temperature away from moisture and light |
| Missed Dose | Take as soon as you remember; skip if it’s almost time for your next dose. Do not double the dose. |
| Alternatives | Aromatase inhibitors (e.g., Anastrozole, Letrozole), Fulvestrant |
Tamoxifen Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Anastrozole (Arimidex) | Aromatase inhibitor; reduces estrogen production | Used in postmenopausal women with hormone receptor-positive breast cancer. |
| Letrozole (Femara) | Aromatase inhibitor; reduces estrogen production | Used in postmenopausal women with hormone receptor-positive breast cancer. |
| Fulvestrant (Faslodex) | Estrogen receptor antagonist | Used in advanced breast cancer in postmenopausal women. |
Tamoxifen Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Hot flashes | Blood clots (DVT, pulmonary embolism) |
| Vaginal discharge | Uterine cancer |
| Mood swings | Stroke |
| Fatigue | Cataracts |
| Nausea | Endometrial changes |
Tamoxifen Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Breast Cancer Treatment | 20-40 mg daily | 20-40 mg daily | May be taken with or without food. Follow doctor’s instructions. |
| Breast Cancer Prevention (High Risk) | 20 mg daily | 20 mg daily | May be taken with or without food. Usually taken for 5 years. |
