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General Medication Fact Sheet for Tasigna
| Field | Information |
|---|---|
| Medication Name | Tasigna |
| Generic Name | Nilotinib |
| Boxed/Label Warning | QT Prolongation, Sudden Death, Arterial Occlusive Events |
| Purpose | Treatment of chronic myeloid leukemia (CML) in patients who are newly diagnosed or resistant/intolerant to prior therapy, specifically in the chronic and accelerated phases. |
| Mechanism of Action | Inhibits the BCR-ABL tyrosine kinase, which is constitutively active in CML cells, thereby blocking the signaling pathways necessary for their proliferation and survival. |
| Dosage Forms | Oral capsules |
| Available Strengths | 150 mg, 200 mg |
| Dosage Frequency | Twice daily, approximately 12 hours apart |
| Common Side Effects | Nausea, fatigue, headache, rash, abdominal pain, constipation, diarrhea, vomiting, myalgia, arthralgia, alopecia, pruritus |
| Serious Side Effects | QT prolongation, sudden death, pancreatitis, liver toxicity, tumor lysis syndrome, peripheral artery occlusive disease, electrolyte abnormalities, bleeding, fluid retention, myelosuppression |
| Drug Interactions | Strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole, clarithromycin), strong CYP3A4 inducers (e.g., rifampin, phenytoin, carbamazepine), QT-prolonging drugs, proton pump inhibitors (PPIs), H2-receptor antagonists |
| Important Notes | Tasigna should be taken on an empty stomach, at least 2 hours before or 1 hour after food. Monitor ECG for QT prolongation. Regular blood counts and liver function tests are necessary. Avoid grapefruit and grapefruit juice. |
| Storage | Store at room temperature, away from moisture and light. Keep out of reach of children. |
| Missed Dose | If a dose is missed, do not take an extra dose. Take the next dose at the regular scheduled time. |
| Alternatives | Gleevec (imatinib), Sprycel (dasatinib), Bosulif (bosutinib), Iclusig (ponatinib) |
Tasigna Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Gleevec (imatinib) | Tyrosine kinase inhibitor | First-generation BCR-ABL inhibitor; often used as first-line treatment for CML. |
| Sprycel (dasatinib) | Tyrosine kinase inhibitor | Second-generation BCR-ABL inhibitor; may be used in patients resistant or intolerant to imatinib. |
| Bosulif (bosutinib) | Tyrosine kinase inhibitor | Second-generation BCR-ABL inhibitor; another option for patients resistant or intolerant to imatinib. |
| Iclusig (ponatinib) | Tyrosine kinase inhibitor | Third-generation BCR-ABL inhibitor; used in patients with T315I mutation or resistant to other TKIs. |
Tasigna Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Nausea | QT prolongation |
| Fatigue | Sudden death |
| Headache | Pancreatitis |
| Rash | Liver toxicity |
| Abdominal Pain | Tumor lysis syndrome |
| Constipation | Peripheral artery occlusive disease |
| Diarrhea | Myelosuppression |
| Vomiting | Electrolyte Abnormalities |
| Myalgia (muscle pain) | Bleeding |
| Arthralgia (joint pain) | Fluid Retention |
Tasigna Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Newly Diagnosed CML-CP | 300 mg twice daily | 300 mg twice daily | Take on an empty stomach, at least 2 hours before or 1 hour after food. |
| Resistant/Intolerant CML-CP | 400 mg twice daily | 400 mg twice daily | Take on an empty stomach, at least 2 hours before or 1 hour after food. |
| Accelerated Phase CML | 400 mg twice daily | 400 mg twice daily | Take on an empty stomach, at least 2 hours before or 1 hour after food. |
Tasigna Price With And Without Insurance
| Purchase Context | Estimated Price |
|---|---|
| With Insurance | $350 |
| Without Insurance (U.S.) | $8,500 |
| From CPS | $4,473 |
