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General Medication Fact Sheet for Tasmar
| Field | Information |
|---|---|
| Medication Name | Tasmar |
| Generic Name | Tolcapone |
| Boxed/Label Warning | Hepatotoxicity (liver damage) – Monitor liver function regularly. |
| Purpose | Treatment of Parkinson’s disease, used with levodopa and carbidopa. |
| Mechanism of Action | Inhibits catechol-O-methyltransferase (COMT), increasing levodopa availability in the brain. |
| Dosage Forms | Oral tablets |
| Available Strengths | 100 mg |
| Dosage Frequency | Typically three times daily with levodopa/carbidopa. |
| Common Side Effects | Dyskinesia (involuntary movements), nausea, diarrhea, orthostatic hypotension (low blood pressure upon standing), sleep disturbances. |
| Serious Side Effects | Hepatotoxicity (liver failure), rhabdomyolysis (muscle breakdown), neuroleptic malignant syndrome (NMS). |
| Drug Interactions | MAO inhibitors (e.g., Selegiline, Rasagiline), isoproterenol, dobutamine, epinephrine, norepinephrine. |
| Important Notes | Regular liver function tests are required. Report any signs of liver problems (e.g., jaundice, dark urine, abdominal pain) immediately. Use with caution in patients with pre-existing liver disease. |
| Storage | Store at room temperature away from moisture and light. |
| Missed Dose | Take as soon as you remember, unless it is almost time for your next dose. Do not double the dose. |
| Alternatives | Entacapone (Comtan), Selegiline (Eldepryl), Rasagiline (Azilect), Opicapone (Ongentys) |
Tasmar Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Entacapone (Comtan) | COMT inhibitor | Another COMT inhibitor; may have a lower risk of liver toxicity than tolcapone. |
| Selegiline (Eldepryl) | MAO-B inhibitor | Inhibits the breakdown of dopamine in the brain. |
| Rasagiline (Azilect) | MAO-B inhibitor | Similar to Selegiline but may be better tolerated by some individuals. |
| Opicapone (Ongentys) | COMT inhibitor | Longer-acting COMT inhibitor, allowing for once-daily dosing. |
Tasmar Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Dyskinesia | Hepatotoxicity (liver failure) |
| Nausea | Rhabdomyolysis (muscle breakdown) |
| Diarrhea | Neuroleptic Malignant Syndrome (NMS) |
| Orthostatic hypotension | Hallucinations |
| Sleep disturbances | Increased risk of melanoma |
Tasmar Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Parkinson’s Disease | 100 mg | 100-200 mg three times daily | Always taken with levodopa/carbidopa. Monitor liver function regularly. |
Tasmar Price With And Without Insurance
| Purchase Context | Estimated Price |
|---|---|
| With Insurance | $50 |
| Without Insurance (U.S.) | $400 |
| From CPS | $242 |
