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General Medication Fact Sheet for Tecfidera
| Field | Information |
|---|---|
| Medication Name | Tecfidera |
| Generic Name | Dimethyl Fumarate |
| Boxed/Label Warning | Progressive multifocal leukoencephalopathy (PML) risk |
| Purpose | Treatment of relapsing forms of multiple sclerosis (MS) |
| Mechanism of Action | Activation of the Nrf2 pathway, which has anti-inflammatory and cytoprotective effects. |
| Dosage Forms | Delayed-release capsules |
| Available Strengths | 120 mg, 240 mg |
| Dosage Frequency | Twice daily |
| Common Side Effects | Flushing, abdominal pain, diarrhea, nausea |
| Serious Side Effects | PML, decreased white blood cell count (lymphopenia), liver injury, severe allergic reactions |
| Drug Interactions | Immunosuppressants, live vaccines, alcohol (may worsen flushing) |
| Important Notes | Monitor for signs and symptoms of PML. Regular blood tests are required to monitor white blood cell counts and liver function. Avoid use with other fumarates. |
| Storage | Store at room temperature between 68°F to 77°F (20°C to 25°C). Protect from light and moisture. |
| Missed Dose | Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose. |
| Alternatives | Gilenya (fingolimod), Aubagio (teriflunomide), Copaxone (glatiramer acetate), Ocrevus (ocrelizumab), Mavenclad (cladribine) |
Tecfidera Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Gilenya (fingolimod) | Sphingosine 1-phosphate receptor modulator | Oral medication; requires first-dose observation due to potential cardiac effects. |
| Aubagio (teriflunomide) | Pyrimidine synthesis inhibitor | Oral medication; teratogenic and requires a washout period before pregnancy. |
| Copaxone (glatiramer acetate) | Synthetic polypeptide | Given by subcutaneous injection; generally well-tolerated. |
| Ocrevus (ocrelizumab) | Anti-CD20 monoclonal antibody | Administered by intravenous infusion every 6 months. |
| Mavenclad (cladribine) | Purine nucleoside analog | Oral medication, administered in two annual treatment courses. |
Tecfidera Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Flushing | Progressive multifocal leukoencephalopathy (PML) |
| Abdominal pain | Decreased white blood cell count (lymphopenia) |
| Diarrhea | Liver injury |
| Nausea | Severe allergic reactions (anaphylaxis, angioedema) |
| Itching | Herpes Zoster (shingles) |
Tecfidera Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Relapsing Multiple Sclerosis | 120 mg twice daily for 7 days | 240 mg twice daily | Take with food to reduce flushing and gastrointestinal side effects. |
Tecfidera Price With And Without Insurance
| Purchase Context | Estimated Price |
|---|---|
| With Insurance | $50 – $200 |
| Without Insurance (U.S.) | $2,600 |
| From CPS | $225 |
