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General Medication Fact Sheet for Temodar
| Field | Information |
|---|---|
| Medication Name | Temodar |
| Generic Name | Temozolomide |
| Boxed/Label Warning | May cause myelosuppression, increasing the risk of infection and bleeding. Use with caution in patients with compromised bone marrow reserve. |
| Purpose | Treatment of certain types of brain tumors, including glioblastoma multiforme and anaplastic astrocytoma. |
| Mechanism of Action | An alkylating agent that damages DNA, leading to cell death in rapidly dividing cells, such as cancer cells. |
| Dosage Forms | Oral capsules, Injection |
| Available Strengths | 5 mg, 20 mg, 100 mg, 140 mg, 180 mg, 250 mg (capsules); Injection Vials Vary |
| Dosage Frequency | Once daily for a specified number of days, followed by a rest period, typically in a cyclic manner. Dosage schedules vary based on cancer type and treatment protocol. |
| Common Side Effects | Nausea, vomiting, fatigue, constipation, headache, hair loss. |
| Serious Side Effects | Myelosuppression (decreased blood cell counts), infections, seizures, liver problems, pneumocystis pneumonia. |
| Drug Interactions | Valproic acid, other myelosuppressive agents, drugs metabolized by CYP3A4 enzymes. |
| Important Notes | Take on an empty stomach to improve absorption. Anti-emetics may be needed to manage nausea and vomiting. Monitor blood counts regularly. Women of childbearing potential should use effective contraception. |
| Storage | Store capsules at room temperature away from moisture and light. |
| Missed Dose | Consult with your healthcare provider immediately for instructions. Do not take a double dose. |
| Alternatives | Carmustine, Lomustine, Bevacizumab, Procarbazine |
Temodar Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Carmustine (BiCNU) | Alkylating agent | Used for various cancers, including brain tumors. |
| Lomustine (Gleostine) | Alkylating agent | Similar to carmustine; used for brain tumors. |
| Bevacizumab (Avastin) | VEGF inhibitor | Inhibits blood vessel growth in tumors. |
| Procarbazine (Matulane) | Alkylating agent, monoamine oxidase inhibitor (MAOI) | Less commonly used, but can be an option in some cases. |
Temodar Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Nausea | Myelosuppression (decreased blood cell counts) |
| Vomiting | Infections |
| Fatigue | Seizures |
| Constipation | Liver problems |
| Headache | Pneumocystis pneumonia (PCP) |
| Hair loss | Blood clots |
Temodar Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Glioblastoma Multiforme (Newly Diagnosed) | 75 mg/m²/day | 150-200 mg/m²/day (cycle 2 onwards, if tolerated) | Administered daily for 42 days concurrently with radiation therapy, followed by 6 cycles as a single agent. |
| Anaplastic Astrocytoma (Refractory) | 150 mg/m²/day | 150-200 mg/m²/day (if tolerated) | Administered for 5 consecutive days every 28-day cycle. |
