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General Medication Fact Sheet for Temozolomide
| Field | Information |
|---|---|
| Generic Name | Temozolomide |
| Brand Name Versions | Temodar |
| Purpose | Treats certain types of brain tumors, such as glioblastoma multiforme and anaplastic astrocytoma |
| Mechanism of Action | An alkylating agent that damages the DNA of cancer cells, leading to cell death. |
| Dosage Forms | Oral capsules |
| Available Strengths | 5 mg, 20 mg, 100 mg, 140 mg, 180 mg, 250 mg |
| Dosage Frequency | Usually once daily for a specified number of days, followed by a rest period, or as directed by a healthcare provider |
| Common Side Effects | Nausea, vomiting, fatigue, headache, constipation, hair loss |
| Serious Side Effects | Severe myelosuppression (decreased blood cell counts), opportunistic infections, pneumocystis pneumonia, liver problems, seizures |
| Drug Interactions | Valproic acid, other myelosuppressive agents |
| Important Notes | Take on an empty stomach, at least one hour before or two hours after a meal; antiemetics may be prescribed to prevent nausea and vomiting; monitor blood counts regularly |
| Storage | Store at room temperature away from moisture and light |
| Missed Dose | Contact your doctor immediately for guidance. Do not take a double dose without consulting your healthcare provider. |
| Alternatives | Lomustine, Carmustine, Bevacizumab, Procarbazine |
Temozolomide Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Lomustine (CeeNU) | Alkylating agent, similar to temozolomide | Oral chemotherapy medication |
| Carmustine (BiCNU) | Alkylating agent | Can be administered intravenously or as a wafer implanted directly into the brain |
| Bevacizumab (Avastin) | Angiogenesis inhibitor | Blocks the growth of new blood vessels that tumors need to grow |
| Procarbazine (Matulane) | Alkylating agent | Another chemotherapy option for brain tumors |
Temozolomide Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Nausea | Severe myelosuppression (decreased blood cell counts) |
| Vomiting | Opportunistic infections |
| Fatigue | Pneumocystis pneumonia |
| Headache | Liver problems |
| Constipation | Seizures |
| Hair Loss | Pulmonary toxicity |
Temozolomide Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Glioblastoma Multiforme (Newly Diagnosed) | 75 mg/m²/day | 150-200 mg/m²/day (cycles) | Concomitant with radiation therapy, followed by adjuvant cycles. Take on an empty stomach. |
| Anaplastic Astrocytoma (Refractory) | 150 mg/m²/day | 150-200 mg/m²/day (cycles) | Take on an empty stomach. Dosage adjustments based on blood counts. |
Temozolomide Price With And Without Insurance
| Purchase Context | Estimated Price |
|---|---|
| With Insurance | $50 – $200 |
| Without Insurance (U.S.) | $475 |
| From CPS | $55 |
