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General Medication Fact Sheet for Tenofovir
| Field | Information |
|---|---|
| Generic Name | Tenofovir |
| Brand Name Versions | Viread |
| Boxed/Label Warning | Lactic acidosis and severe hepatomegaly with steatosis, post-treatment acute exacerbation of hepatitis B |
| Purpose | Antiretroviral medication used to treat HIV and chronic hepatitis B |
| Mechanism of Action | Inhibits reverse transcriptase, an enzyme crucial for viral replication |
| Dosage Forms | Oral tablets, Oral powder |
| Available Strengths | 150 mg, 200 mg, 250 mg, 300 mg |
| Dosage Frequency | Typically once daily, or as directed by a healthcare provider |
| Common Side Effects | Nausea, vomiting, diarrhea, headache, dizziness |
| Serious Side Effects | Kidney problems, bone problems (osteomalacia), lactic acidosis, liver problems |
| Drug Interactions | Didanosine, atazanavir, lopinavir/ritonavir, aminoglycosides, amphotericin B, NSAIDs |
| Important Notes | Regular monitoring of kidney function and bone density is recommended |
| Storage | Store at room temperature away from moisture and light |
| Missed Dose | Take as soon as you remember; skip if it’s almost time for your next dose. Do not double the dose. |
| Alternatives | Emtricitabine, Abacavir, Lamivudine, Zidovudine |
Tenofovir Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Emtricitabine (Emtriva) | Inhibits reverse transcriptase | Another nucleoside reverse transcriptase inhibitor (NRTI) used to treat HIV. |
| Abacavir (Ziagen) | Inhibits reverse transcriptase | An NRTI; requires genetic testing (HLA-B*5701) to rule out hypersensitivity. |
| Lamivudine (Epivir) | Inhibits reverse transcriptase | An NRTI; also used to treat hepatitis B. |
| Zidovudine (Retrovir) | Inhibits reverse transcriptase | An NRTI; one of the first drugs used to treat HIV. |
Tenofovir Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Nausea | Kidney problems |
| Vomiting | Bone problems (osteomalacia) |
| Diarrhea | Lactic acidosis |
| Headache | Liver problems |
| Dizziness | Fanconi syndrome |
Tenofovir Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| HIV Infection | 300 mg | 300 mg once daily | Take with or without food. |
| Chronic Hepatitis B | 300 mg | 300 mg once daily | Take with or without food. |
