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General Medication Fact Sheet for Teriflunomide
| Field | Information |
|---|---|
| Generic Name | Teriflunomide |
| Brand Name Versions | Aubagio |
| Boxed/Label Warning | Teriflunomide can cause severe liver problems. Tell your doctor if you have ever had liver problems. It can also cause serious harm to an unborn baby. Females must use effective birth control during treatment and for up to 2 years after stopping treatment. |
| Purpose | Disease-modifying therapy for multiple sclerosis (MS) |
| Mechanism of Action | Inhibits dihydroorotate dehydrogenase, reducing pyrimidine synthesis and lymphocyte proliferation |
| Dosage Forms | Oral tablets |
| Available Strengths | 7 mg, 14 mg |
| Dosage Frequency | Once daily |
| Common Side Effects | Headache, nausea, diarrhea, hair thinning, elevated liver enzymes |
| Serious Side Effects | Liver damage, peripheral neuropathy, severe infections, increased blood pressure, allergic reactions |
| Drug Interactions | Leflunomide, other hepatotoxic drugs, warfarin, live vaccines, rifampin |
| Important Notes | Monitor liver function regularly. Avoid live vaccines. Use effective contraception if female. Contact your doctor immediately if you experience symptoms of liver injury (e.g., jaundice, dark urine, abdominal pain). |
| Storage | Store at room temperature away from moisture and light. |
| Missed Dose | Take as soon as you remember. If it’s almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose. |
| Alternatives | Interferon beta-1a, Glatiramer acetate, Dimethyl fumarate, Fingolimod |
Teriflunomide Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Interferon beta-1a (Avonex, Rebif) | Modulates immune response | Administered via intramuscular or subcutaneous injection. |
| Glatiramer acetate (Copaxone) | Alters immune processes | Administered via subcutaneous injection. |
| Dimethyl fumarate (Tecfidera) | Activates Nrf2 pathway | Oral medication. Common side effects include flushing and gastrointestinal upset. |
| Fingolimod (Gilenya) | Sphingosine 1-phosphate receptor modulator | Oral medication. Requires first-dose observation due to potential cardiac effects. |
Teriflunomide Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Headache | Liver damage |
| Nausea | Peripheral neuropathy |
| Diarrhea | Severe infections (e.g., pneumonia, herpes zoster) |
| Hair thinning | Increased blood pressure |
| Elevated liver enzymes | Allergic reactions (rash, itching, swelling, difficulty breathing) |
Teriflunomide Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Multiple Sclerosis (MS) | 7 mg or 14 mg | 7 mg or 14 mg once daily | Take orally, with or without food. |
Teriflunomide Price With And Without Insurance
| Purchase Context | Estimated Price |
|---|---|
| With Insurance | $60 |
| Without Insurance (U.S.) | $6000 – $8000 |
| From Canada | $660 |
