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General Medication Fact Sheet for Teriparatide Injections
| Field | Information |
|---|---|
| Generic Name | Teriparatide |
| Brand Name Versions | Forteo, Bonsity |
| Boxed/Label Warning | May cause osteosarcoma (bone cancer). Use should be balanced against the potential benefits. |
| Purpose | Treatment of osteoporosis in postmenopausal women and men at high risk for fracture. |
| Mechanism of Action | Anabolic (bone-building) agent; recombinant parathyroid hormone that stimulates new bone formation. |
| Dosage Forms | Subcutaneous injection |
| Available Strengths | 20 mcg/80 mcg per prefilled pen (delivering 20 mcg per dose) |
| Dosage Frequency | Once daily |
| Common Side Effects | Joint pain, nausea, headache, dizziness, leg cramps. |
| Serious Side Effects | Osteosarcoma (bone cancer), hypercalcemia (high calcium levels), orthostatic hypotension (low blood pressure upon standing). |
| Drug Interactions | Digoxin (monitor closely for toxicity), other calcium supplements (increased risk of hypercalcemia). |
| Important Notes | Rotate injection sites daily. Do not use for more than two years over a lifetime. Sit or lie down if you feel dizzy after injecting. |
| Storage | Refrigerate the prefilled pen before first use; protect from light. After first use, the pen can be stored at room temperature for up to 28 days. |
| Missed Dose | Take the missed dose as soon as you remember that day. Do not take two injections on the same day. |
| Alternatives | Alendronate, Risedronate, Ibandronate, Zoledronic Acid, Denosumab |
Teriparatide Injections Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Alendronate (Fosamax) | Bisphosphonate; inhibits bone resorption. | Oral medication taken weekly or daily. |
| Risedronate (Actonel) | Bisphosphonate; inhibits bone resorption. | Oral medication taken weekly, monthly, or daily. |
| Ibandronate (Boniva) | Bisphosphonate; inhibits bone resorption. | Oral medication taken monthly or IV injection quarterly. |
| Zoledronic Acid (Reclast) | Bisphosphonate; inhibits bone resorption. | Intravenous infusion administered once yearly. |
| Denosumab (Prolia) | RANKL inhibitor; inhibits osteoclast formation and bone resorption. | Subcutaneous injection administered every 6 months. |
Teriparatide Injections Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Joint pain | Osteosarcoma (bone cancer) |
| Nausea | Hypercalcemia (high calcium levels) |
| Headache | Orthostatic hypotension (low blood pressure upon standing) |
| Dizziness | Increased risk of kidney stones |
| Leg cramps | Allergic reactions (rash, itching, swelling, difficulty breathing) |
Teriparatide Injections Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Osteoporosis (Postmenopausal Women) | 20 mcg | 20 mcg daily | Subcutaneous injection in the thigh or abdomen; rotate sites. |
| Osteoporosis (Men) | 20 mcg | 20 mcg daily | Subcutaneous injection in the thigh or abdomen; rotate sites. |
| Glucocorticoid-Induced Osteoporosis | 20 mcg | 20 mcg daily | Subcutaneous injection in the thigh or abdomen; rotate sites. |
Teriparatide Injections Price With And Without Insurance
| Purchase Context | Estimated Price |
|---|---|
| With Insurance | $25 |
| Without Insurance (U.S.) | $5600 |
| From Canada | $900 |
