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General Medication Fact Sheet for Thioridazine
| Field | Information |
|---|---|
| Medication Name | Thioridazine |
| Generic Name | Thioridazine |
| Boxed/Label Warning | Increased mortality in elderly patients with dementia-related psychosis. QT prolongation and risk of torsades de pointes. |
| Purpose | Treats schizophrenia |
| Mechanism of Action | Blocks dopamine receptors in the brain |
| Dosage Forms | Oral tablets |
| Available Strengths | 10 mg, 15 mg, 25 mg, 50 mg, 100 mg |
| Dosage Frequency | 2 to 4 times daily, as directed by a healthcare provider |
| Common Side Effects | Drowsiness, dry mouth, blurred vision, constipation, dizziness, nasal congestion, weight gain |
| Serious Side Effects | Tardive dyskinesia, neuroleptic malignant syndrome, QT prolongation, seizures, orthostatic hypotension, blood dyscrasias |
| Drug Interactions | Other antipsychotics, antiarrhythmics, SSRIs, TCAs, medications that prolong the QT interval, CYP2D6 inhibitors (e.g., fluoxetine, paroxetine), alcohol, CNS depressants |
| Important Notes | Monitor ECG for QT prolongation. Avoid alcohol. Use caution when driving or operating machinery. Inform your doctor of all medications you are taking. |
| Storage | Store at room temperature away from moisture and light |
| Missed Dose | Take as soon as you remember; skip if it’s almost time for your next dose. Do not double the dose. Consult your doctor. |
| Alternatives | Chlorpromazine, Haloperidol, Risperidone, Quetiapine |
Thioridazine Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Chlorpromazine | Dopamine receptor antagonist | First-generation antipsychotic. Similar side effect profile to thioridazine. |
| Haloperidol | Dopamine receptor antagonist | High potency first-generation antipsychotic. Greater risk of extrapyramidal symptoms. |
| Risperidone | Dopamine and serotonin receptor antagonist | Second-generation antipsychotic with a different side effect profile. |
| Quetiapine (Seroquel) | Dopamine and serotonin receptor antagonist | Second-generation antipsychotic. Often used for its sedative effects. |
Thioridazine Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Drowsiness | Tardive dyskinesia (TD) |
| Dry mouth | Neuroleptic Malignant Syndrome (NMS) |
| Blurred vision | QT prolongation / Torsades de Pointes |
| Constipation | Seizures |
| Dizziness | Orthostatic Hypotension |
| Nasal congestion | Blood dyscrasias (agranulocytosis, leukopenia, thrombocytopenia) |
| Weight gain | Retinal pigmentation |
Thioridazine Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Schizophrenia (Adults) | 50-100 mg | 200-800 mg daily (divided doses) | Administer 2 to 4 times daily. Adjust dosage based on response and tolerability. Monitor ECG. |
| Schizophrenia (Geriatric or Debilitated Patients) | Lower initial dose | Gradually increase to effective dose | Start at the lower end of the dosage range. Titrate slowly. |
Thioridazine Price With And Without Insurance
| Purchase Context | Estimated Price |
|---|---|
| With Insurance | $25 |
| Without Insurance (U.S.) | $40 |
| From Canada | $28 |
