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Tizanidine (Generic)
| Zanaflex Tizanidine Hydrochloride | ||||||
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Shipped from Mauritius | ||||||
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General Medication Fact Sheet for Tizanidine
| Field | Information |
|---|---|
| Generic Name | Tizanidine |
| Brand Name Versions | Zanaflex |
| Boxed/Label Warning | Tizanidine can cause significant hypotension. Monitor patients closely for hypotension, bradycardia, and excessive drowsiness. Avoid use with potent CYP1A2 inhibitors. |
| Purpose | Muscle relaxant used to treat muscle spasms. |
| Mechanism of Action | Alpha-2 adrenergic agonist, reduces release of excitatory amino acids in the spinal cord. |
| Dosage Forms | Oral tablets, oral capsules |
| Available Strengths | Tablets: 2 mg, 4 mg; Capsules: 2 mg, 4 mg, 6 mg |
| Dosage Frequency | Typically taken every 6-8 hours as needed, up to three times daily. |
| Common Side Effects | Drowsiness, dizziness, dry mouth, weakness. |
| Serious Side Effects | Hypotension (low blood pressure), bradycardia (slow heart rate), liver damage. |
| Drug Interactions | CYP1A2 inhibitors (e.g., fluvoxamine, ciprofloxacin), alcohol, other CNS depressants. |
| Important Notes | Avoid alcohol. Use caution when driving or operating machinery. Rise slowly from a sitting or lying position to avoid dizziness. |
| Storage | Store at room temperature away from moisture and light. |
| Missed Dose | Take as soon as you remember, unless it is almost time for your next dose. Do not double the dose. |
| Alternatives | Baclofen, Cyclobenzaprine, Diazepam, Methocarbamol. |
Tizanidine Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Baclofen (Lioresal) | GABA-B receptor agonist | May be more effective for spasticity related to spinal cord injury or multiple sclerosis. |
| Cyclobenzaprine (Flexeril) | Central muscle relaxant; mechanism not fully understood | Commonly used for acute muscle spasms. Can cause drowsiness. |
| Diazepam (Valium) | Benzodiazepine; enhances GABA activity | Has sedative and anxiolytic effects. Potential for dependence. |
| Methocarbamol (Robaxin) | Central muscle relaxant; mechanism not fully understood | Generally well-tolerated, but can cause drowsiness. |
Tizanidine Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Drowsiness | Hypotension (low blood pressure) |
| Dizziness | Bradycardia (slow heart rate) |
| Dry mouth | Liver damage (rare) |
| Weakness | Hallucinations |
| Fatigue | Increased muscle spasms (rebound effect upon discontinuation) |
Tizanidine Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Muscle Spasms | 2 mg | 2-4 mg every 6-8 hours as needed (max 3 doses in 24 hours) | Start with a low dose to minimize side effects. Adjust dose based on response and tolerance. |
