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Topiramate (Generic)
| Topamax Topiramate | ||||||
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Shipped from Canada | ||||||
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| Topamax Sprinkle Topiramate | ||||||
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Shipped from Canada | ||||||
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Who is the product for? YouOtherAdd Family Member/PetYou must be logged in to add additional members to the order. Don't have an account? or Add Family Member/PetSign inTo continue, please enter your email address and password that you use for your account. | ||||||
| Select product strength & quantity:
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General Medication Fact Sheet for Topiramate
| Field | Information |
|---|---|
| Generic Name | Topiramate |
| Brand Name Versions | Topamax, Trokendi XR, Qudexy XR |
| Boxed/Label Warning | This medication can cause acute myopia and secondary angle closure glaucoma, characterized by decreased visual acuity or ocular pain. Discontinue topiramate if these symptoms occur. |
| Purpose | Antiepileptic drug used to prevent seizures and treat migraines |
| Mechanism of Action | Blocks sodium channels, enhances GABA activity, antagonizes AMPA/kainate glutamate receptors, and weakly inhibits carbonic anhydrase |
| Dosage Forms | Oral tablets, sprinkle capsules, extended-release capsules |
| Available Strengths | 25 mg, 50 mg, 100 mg, 200 mg |
| Dosage Frequency | Typically once or twice daily, as directed by a healthcare provider |
| Common Side Effects | Tingling in extremities, weight loss, loss of appetite, speech problems, difficulty concentrating, fatigue, dizziness |
| Serious Side Effects | Kidney stones, metabolic acidosis, glaucoma, suicidal thoughts, cognitive problems |
| Drug Interactions | Other antiepileptic drugs (e.g., Valproic Acid, phenytoin), carbonic anhydrase inhibitors (e.g., acetazolamide), oral contraceptives, alcohol |
| Important Notes | Drink plenty of fluids to prevent kidney stones; do not stop taking suddenly; may impair thinking or reaction time; can cause birth defects if taken during pregnancy. |
| Storage | Store at room temperature away from moisture and light |
| Missed Dose | Take as soon as you remember; skip if it’s almost time for your next dose. Do not double the dose. |
| Alternatives | For Epilepsy: Lamotrigine, Levetiracetam, Valproic Acid For Migraine: Propranolol, Amitriptyline, Erenumab (Aimovig) |
Topiramate Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Lamotrigine (Lamictal) | Blocks voltage-sensitive sodium channels, stabilizes neuronal membranes | Used for epilepsy and bipolar disorder. |
| Levetiracetam (Keppra) | Binds to synaptic vesicle protein 2A (SV2A), modulating neurotransmitter release | Commonly used for epilepsy. |
| Valproic Acid (Depakote) | Increases GABA levels, blocks sodium channels | Used for epilepsy, bipolar disorder, and migraine prophylaxis. |
| Propranolol (Inderal) | Beta-adrenergic blocker | Used for migraine prophylaxis, hypertension, and anxiety. |
| Amitriptyline (Elavil) | Tricyclic antidepressant, blocks reuptake of serotonin and norepinephrine | Used for migraine prophylaxis and depression. |
| Erenumab (Aimovig) | Monoclonal antibody targeting the CGRP receptor | Specifically for migraine prevention. |
Topiramate Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Tingling in extremities | Kidney stones |
| Weight loss | Metabolic acidosis |
| Loss of appetite | Glaucoma |
| Speech problems | Suicidal thoughts |
| Difficulty concentrating | Cognitive problems (memory and concentration difficulties) |
| Fatigue | Oligohidrosis (decreased sweating) leading to hyperthermia in children |
| Dizziness | Acute Myopia and Secondary Angle Closure Glaucoma |
Topiramate Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Epilepsy (Adults) | 25-50 mg daily | 200-400 mg daily in two divided doses | Titrate slowly; can be taken with or without food. |
| Epilepsy (Children) | 0.5-1 mg/kg daily | 5-9 mg/kg daily in two divided doses | Titrate slowly; sprinkle capsules can be opened and sprinkled on soft food. |
| Migraine Prophylaxis (Adults) | 25 mg daily | 50 mg twice daily | Titrate slowly; can be taken with or without food. |
