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Trelegy Ellipta (Fluticasone Furoate, Umeclidinium, Vilanterol Trifenatate)
General Medication Fact Sheet for Trelegy Ellipta
| Field | Information |
|---|---|
| Medication Name | Trelegy Ellipta |
| Generic Name | Fluticasone furoate/umeclidinium/vilanterol |
| Boxed/Label Warning | Increased risk of asthma-related death when used in patients whose asthma is adequately controlled on long-term asthma control medications, such as inhaled corticosteroids. |
| Purpose | Maintenance treatment of chronic obstructive pulmonary disease (COPD), including chronic bronchitis and/or emphysema; also used for asthma in some patients. |
| Mechanism of Action | Fluticasone furoate is an inhaled corticosteroid that reduces inflammation; umeclidinium is a long-acting muscarinic antagonist (LAMA) that relaxes airway muscles; vilanterol is a long-acting beta2-adrenergic agonist (LABA) that also relaxes airway muscles. |
| Dosage Forms | Inhalation powder (Ellipta inhaler) |
| Available Strengths | 100/62.5/25 mcg (fluticasone furoate/umeclidinium/vilanterol) per inhalation; 200/62.5/25 mcg (fluticasone furoate/umeclidinium/vilanterol) per inhalation. |
| Dosage Frequency | Once daily |
| Common Side Effects | Upper respiratory tract infection, nasopharyngitis, headache, bronchitis, back pain, pneumonia. |
| Serious Side Effects | Pneumonia, serious allergic reactions, decreased bone mineral density, glaucoma, increased intraocular pressure, paradoxical bronchospasm, hypercorticism and adrenal suppression, cardiovascular effects. |
| Drug Interactions | Strong CYP3A4 inhibitors (e.g., ketoconazole), beta-blockers, other long-acting beta2-adrenergic agonists (LABAs), anticholinergics. |
| Important Notes | Not for the relief of acute bronchospasm. Rinse mouth after each use to prevent oral thrush. Use with caution in patients with cardiovascular disorders, glaucoma, or urinary retention. |
| Storage | Store at room temperature in a dry place. Keep the inhaler sealed until ready for use. |
| Missed Dose | Take as soon as you remember. If it is almost time for your next dose, skip the missed dose and take your next dose at the regular time. Do not take two doses at once. |
| Alternatives | Advair Diskus (fluticasone/salmeterol), Symbicort (budesonide/formoterol), Breo Ellipta (fluticasone furoate/vilanterol), Anoro Ellipta (umeclidinium/vilanterol) |
Trelegy Ellipta Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Advair Diskus (fluticasone/salmeterol) | Inhaled corticosteroid/LABA | Contains a corticosteroid and a long-acting bronchodilator. Does not contain a LAMA. |
| Symbicort (budesonide/formoterol) | Inhaled corticosteroid/LABA | Contains a corticosteroid and a long-acting bronchodilator. Does not contain a LAMA. |
| Breo Ellipta (fluticasone furoate/vilanterol) | Inhaled corticosteroid/LABA | Similar to Advair and Symbicort, but with different active ingredients. Does not contain a LAMA. |
| Anoro Ellipta (umeclidinium/vilanterol) | LAMA/LABA | Combines a long-acting muscarinic antagonist and a long-acting bronchodilator. Does not contain an inhaled corticosteroid. |
Trelegy Ellipta Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Upper respiratory tract infection | Pneumonia |
| Nasopharyngitis | Serious allergic reactions (rash, itching, swelling, difficulty breathing) |
| Headache | Decreased bone mineral density |
| Bronchitis | Glaucoma and increased intraocular pressure |
| Back pain | Paradoxical bronchospasm |
| Oral thrush (candidiasis) | Hypercorticism and adrenal suppression |
| Dysphonia (hoarseness) | Cardiovascular effects (chest pain, fast heart rate, tremors, nervousness) |
Trelegy Ellipta Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| COPD | 1 inhalation of 100/62.5/25 mcg once daily | 1 inhalation of 100/62.5/25 mcg once daily | Administer one inhalation once daily. Do not use more than once daily. Rinse mouth after use. |
| Asthma (if indicated) | 1 inhalation of 100/62.5/25 mcg or 200/62.5/25 mcg once daily | 1 inhalation of 100/62.5/25 mcg or 200/62.5/25 mcg once daily | Administer one inhalation once daily. Do not use more than once daily. Rinse mouth after use. Dosage depends on severity of asthma as determined by healthcare provider. |
Trelegy Ellipta Price With And Without Insurance
| Purchase Context | Estimated Price |
|---|---|
| With Insurance | $25 – $50 |
| Without Insurance (U.S.) | $880 |
| From Canada | $156 |
