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General Medication Fact Sheet for Trental
| Field | Information |
|---|---|
| Medication Name | Trental |
| Generic Name | Pentoxifylline |
| Purpose | Treats intermittent claudication (leg pain due to poor blood flow) |
| Mechanism of Action | Improves blood flow by increasing red blood cell flexibility and decreasing blood viscosity. |
| Dosage Forms | Extended-release tablets |
| Available Strengths | 400 mg |
| Dosage Frequency | Typically three times daily, or as directed by a healthcare provider |
| Common Side Effects | Nausea, vomiting, dizziness, headache |
| Serious Side Effects | Chest pain, irregular heartbeat, shortness of breath, severe allergic reaction |
| Drug Interactions | Anticoagulants (e.g., warfarin), antiplatelet drugs (e.g., aspirin, clopidogrel), theophylline |
| Important Notes | Take with food to minimize stomach upset. Avoid alcohol. Consult your doctor if you have heart or kidney problems. |
| Storage | Store at room temperature away from moisture and light. |
| Missed Dose | Take as soon as you remember; skip if it’s almost time for your next dose. Do not double the dose. |
| Alternatives | Pletal (cilostazol), Aspirin, Exercise Therapy |
Trental Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Pletal (cilostazol) | Phosphodiesterase III inhibitor; vasodilator and antiplatelet agent. | Improves blood flow by dilating blood vessels and preventing platelet aggregation. |
| Aspirin | Antiplatelet agent; inhibits thromboxane A2 production. | Reduces the risk of blood clot formation. |
| Exercise Therapy | Non-pharmacological intervention. | Regular exercise can improve circulation and reduce symptoms of intermittent claudication. |
Trental Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Nausea | Chest pain |
| Vomiting | Irregular heartbeat |
| Dizziness | Shortness of breath |
| Headache | Severe allergic reaction (rash, itching, swelling, difficulty breathing) |
| Indigestion | Bleeding (rare) |
Trental Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Intermittent Claudication | 400 mg | 400 mg three times daily | Take with food to minimize stomach upset. |
