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General Medication Fact Sheet for Trifluoperazine
| Field | Information |
|---|---|
| Generic Name | Trifluoperazine |
| Brand Name Versions | Stelazine (no longer available in the U.S.) |
| Boxed/Label Warning | Elderly patients with dementia-related psychosis treated with antipsychotic drugs are at an increased risk of death. |
| Purpose | Antipsychotic medication used to treat schizophrenia and anxiety. |
| Mechanism of Action | Blocks dopamine receptors in the brain. |
| Dosage Forms | Oral tablets |
| Available Strengths | 1 mg, 2 mg, 5 mg, 10 mg |
| Dosage Frequency | Typically two to three times daily, or as directed by a healthcare provider. |
| Common Side Effects | Drowsiness, dizziness, dry mouth, blurred vision, constipation, muscle stiffness. |
| Serious Side Effects | Tardive dyskinesia, neuroleptic malignant syndrome, seizures, irregular heartbeat, severe allergic reactions. |
| Drug Interactions | Other antipsychotics, sedatives, antihistamines, anticholinergics, alcohol, CNS depressants. |
| Important Notes | May cause drowsiness; avoid driving or operating heavy machinery until you know how this medication affects you. Consult a doctor if you experience uncontrolled muscle movements. |
| Storage | Store at room temperature away from moisture and light. |
| Missed Dose | Take as soon as you remember; skip if it’s almost time for your next dose. Do not double the dose. |
| Alternatives | Haloperidol, Risperidone (Risperdal), Quetiapine (Seroquel), Aripiprazole (Abilify) |
Trifluoperazine Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Haloperidol (Haldol) | Blocks dopamine receptors in the brain. | A first-generation antipsychotic. |
| Risperidone (Risperdal) | Blocks dopamine and serotonin receptors. | A second-generation antipsychotic with a lower risk of some side effects. |
| Quetiapine (Seroquel) | Blocks dopamine and serotonin receptors. | A second-generation antipsychotic, often used at lower doses for sleep. |
| Aripiprazole (Abilify) | Partial dopamine agonist and serotonin receptor modulator. | A third-generation antipsychotic with a different mechanism of action. |
Trifluoperazine Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Drowsiness | Tardive dyskinesia (uncontrolled muscle movements) |
| Dizziness | Neuroleptic malignant syndrome (NMS) |
| Dry mouth | Seizures |
| Blurred vision | Irregular heartbeat |
| Constipation | Severe allergic reactions (rash, itching, swelling, difficulty breathing) |
| Muscle stiffness | Falls (due to dizziness or drowsiness) |
Trifluoperazine Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Schizophrenia | 2-5 mg twice daily | 15-20 mg daily (in divided doses) | Adjust dose based on response. |
| Anxiety | 1-2 mg twice daily | 1-6 mg daily (in divided doses) | Use lowest effective dose. |
Trifluoperazine Price With And Without Insurance
| Purchase Context | Estimated Price |
|---|---|
| With Insurance | $20 |
| Without Insurance (U.S.) | $35 |
| From Canada | $15 |

