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General Medication Fact Sheet for Trimipramine
| Field | Information |
|---|---|
| Generic Name | Trimipramine |
| Brand Name Versions | Surmontil |
| Boxed/Label Warning | Antidepressants may increase the risk of suicidal thoughts and behavior in children, adolescents, and young adults. |
| Purpose | Tricyclic antidepressant used to treat depression. |
| Mechanism of Action | Inhibits the reuptake of norepinephrine and serotonin in the brain, increasing their levels. |
| Dosage Forms | Oral capsules |
| Available Strengths | 25 mg, 50 mg, 100 mg |
| Dosage Frequency | Typically taken once daily at bedtime, or divided into multiple doses throughout the day, as directed by a healthcare provider. |
| Common Side Effects | Drowsiness, dry mouth, blurred vision, constipation, urinary retention, dizziness, weight gain. |
| Serious Side Effects | Irregular heartbeat, seizures, confusion, hallucinations, severe constipation, difficulty urinating, glaucoma. |
| Drug Interactions | MAO inhibitors, SSRIs, SNRIs, other antidepressants, alcohol, certain antihistamines, anticholinergics, blood pressure medications, thyroid medications. |
| Important Notes | May cause drowsiness; use caution when driving or operating machinery. Avoid alcohol. Notify your doctor of any other medications you are taking. |
| Storage | Store at room temperature away from moisture and light. |
| Missed Dose | Take as soon as you remember unless it’s almost time for your next dose. Do not double the dose. |
| Alternatives | Amitriptyline, Nortriptyline, Imipramine, Desipramine |
Trimipramine Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Amitriptyline (Elavil) | Tricyclic antidepressant; inhibits reuptake of serotonin and norepinephrine. | Often used for chronic pain and migraine prophylaxis. |
| Nortriptyline (Pamelor) | Tricyclic antidepressant; inhibits reuptake of serotonin and norepinephrine. | Generally has fewer side effects than Amitriptyline. |
| Imipramine (Tofranil) | Tricyclic antidepressant; inhibits reuptake of serotonin and norepinephrine. | Also used for bedwetting in children. |
| Desipramine (Norpramin) | Tricyclic antidepressant; primarily inhibits norepinephrine reuptake. | May be better tolerated in some patients. |
Trimipramine Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Drowsiness | Irregular heartbeat |
| Dry mouth | Seizures |
| Blurred vision | Confusion |
| Constipation | Hallucinations |
| Urinary retention | Severe constipation |
| Dizziness | Difficulty urinating |
| Weight gain | Glaucoma |
Trimipramine Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Depression | 25-75 mg daily | 50-150 mg daily (may be adjusted based on response and tolerance) | May be given in divided doses or as a single dose at bedtime. |
Trimipramine Price With And Without Insurance
| Purchase Context | Estimated Price |
|---|---|
| With Insurance | $25 |
| Without Insurance (U.S.) | $130 – $500 |
| From Canada | $45 |
