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General Medication Fact Sheet for Trulance
| Field | Information |
|---|---|
| Medication Name | Trulance |
| Generic Name | Plecanatide |
| Purpose | Treatment of chronic idiopathic constipation (CIC) and irritable bowel syndrome with constipation (IBS-C) |
| Mechanism of Action | Guanylate cyclase-C (GC-C) agonist; increases fluid secretion in the intestines |
| Dosage Forms | Oral tablets |
| Available Strengths | 3 mg |
| Dosage Frequency | Once daily |
| Common Side Effects | Diarrhea, nausea, abdominal pain, gas |
| Serious Side Effects | Severe diarrhea, dehydration |
| Drug Interactions | No significant drug interactions have been identified |
| Important Notes | Avoid use in patients less than 6 years of age due to risk of dehydration. Use with caution in patients 6 to less than 18 years of age. |
| Storage | Store at room temperature away from moisture and light |
| Missed Dose | Take as soon as you remember; skip if it’s almost time for your next dose. Do not double the dose. |
| Alternatives | Linzess (linaclotide), Amitiza (lubiprostone), Lactulose, Polyethylene Glycol 3350 (MiraLAX) |
Trulance Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Linzess (linaclotide) | Guanylate cyclase-C (GC-C) agonist | Similar mechanism to Trulance; also used for CIC and IBS-C. |
| Amitiza (lubiprostone) | Chloride channel activator | Increases fluid secretion in the intestines. |
| Lactulose | Osmotic laxative | Draws water into the colon, softening the stool. |
| Polyethylene Glycol 3350 (MiraLAX) | Osmotic laxative | Draws water into the colon, softening the stool. |
Trulance Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Diarrhea | Severe diarrhea leading to dehydration |
| Nausea | Dizziness, lightheadedness, or fainting (signs of dehydration) |
| Abdominal pain | Severe allergic reaction (hives, difficulty breathing, swelling of the face/throat) |
Trulance Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Chronic Idiopathic Constipation (CIC) | 3 mg | 3 mg once daily | Take once daily with or without food. |
| Irritable Bowel Syndrome with Constipation (IBS-C) | 3 mg | 3 mg once daily | Take once daily with or without food. |
Trulance Price With And Without Insurance
| Purchase Context | Estimated Price |
|---|---|
| With Insurance | $25 |
| Without Insurance (U.S.) | $700 |
| From Canada | $258 |
