| Medication Name | Trulicity |
| Generic Name | Dulaglutide |
| Boxed/Label Warning | Possible risk of thyroid C-cell tumors, including medullary thyroid carcinoma (MTC). Avoid use in patients with a personal or family history of MTC or in patients with Multiple Endocrine Neoplasia syndrome type 2 (MEN 2). |
| Purpose | To improve blood sugar control in adults with type 2 diabetes mellitus, and to reduce the risk of major cardiovascular events in adults with type 2 diabetes mellitus who have established cardiovascular disease or multiple cardiovascular risk factors. |
| Mechanism of Action | A glucagon-like peptide-1 (GLP-1) receptor agonist. It enhances glucose-dependent insulin secretion, suppresses glucagon secretion, and slows gastric emptying. |
| Dosage Forms | Subcutaneous injection |
| Available Strengths | 0.75 mg/0.5 mL, 1.5 mg/0.5 mL, 3 mg/0.5 mL, 4.5 mg/0.5 mL |
| Dosage Frequency | Once weekly |
| Common Side Effects | Nausea, diarrhea, vomiting, abdominal pain, decreased appetite, fatigue |
| Serious Side Effects | Pancreatitis, gallbladder problems (cholecystitis, cholelithiasis), kidney problems, severe allergic reactions, low blood sugar (hypoglycemia if used with insulin or sulfonylureas), diabetic retinopathy complications |
| Drug Interactions | Insulin, sulfonylureas (e.g., glipizide, glyburide), drugs that affect gastric emptying |
| Important Notes | Inform your doctor if you have a history of pancreatitis, gallbladder problems, or kidney problems. Monitor for signs and symptoms of pancreatitis and gallbladder disease. Patients using Trulicity with insulin or sulfonylureas may be at risk of hypoglycemia. |
| Storage | Store refrigerated at 36°F to 46°F (2°C to 8°C) in the original carton to protect from light. If needed, Trulicity can be stored unrefrigerated for up to 14 days at temperatures not to exceed 86°F (30°C). Do not freeze. |
| Missed Dose | Administer the missed dose as soon as possible if there are at least 3 days (72 hours) until the next scheduled dose. If there are less than 3 days until the next scheduled dose, skip the missed dose and administer the next dose on the regularly scheduled day. |
| Alternatives | Ozempic (semaglutide), Mounjaro (tirzepatide), Victoza (liraglutide), Rybelsus (semaglutide), Jardiance (empagliflozin) |