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General Medication Fact Sheet for Tygacil
| Field | Information |
|---|---|
| Medication Name | Tygacil |
| Generic Name | Tigecycline |
| Boxed/Label Warning | Increased risk of death when compared to other antibiotics. Reserve for use when other alternatives are not suitable. |
| Purpose | Antibiotic used to treat serious infections, including complicated skin and skin structure infections, complicated intra-abdominal infections, and community-acquired bacterial pneumonia. |
| Mechanism of Action | Binds to the 30S ribosomal subunit, inhibiting protein synthesis in bacteria. |
| Dosage Forms | Intravenous (IV) Injection |
| Available Strengths | 50 mg |
| Dosage Frequency | Twice daily (every 12 hours) administered intravenously. |
| Common Side Effects | Nausea, vomiting, diarrhea, abdominal pain, headache. |
| Serious Side Effects | Increased risk of death, pancreatitis, severe allergic reactions, liver problems, Clostridium difficile-associated diarrhea. |
| Drug Interactions | Warfarin (increases risk of bleeding), oral contraceptives (may decrease effectiveness). |
| Important Notes | Must be administered by a healthcare professional via IV. Complete the full course of treatment, even if symptoms improve. Report any signs of allergic reaction or severe side effects to your doctor immediately. |
| Storage | Store unopened vials at controlled room temperature. Reconstituted solution should be used immediately. |
| Missed Dose | Contact your healthcare provider immediately to reschedule the missed dose. It’s crucial to maintain consistent antibiotic levels. |
| Alternatives | Meropenem, Imipenem/Cilastatin, Doripenem, Ertapenem |
Tygacil Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Meropenem (Merrem) | Carbapenem antibiotic that inhibits bacterial cell wall synthesis. | Broad-spectrum antibiotic, often used for serious infections. |
| Imipenem/Cilastatin (Primaxin) | Carbapenem antibiotic; cilastatin prevents degradation of imipenem. | Broad-spectrum antibiotic for various bacterial infections. |
| Doripenem (Doribax) | Carbapenem antibiotic that inhibits bacterial cell wall synthesis. | Used for complicated intra-abdominal and urinary tract infections. |
| Ertapenem (Invanz) | Carbapenem antibiotic that inhibits bacterial cell wall synthesis. | Often used for community-acquired pneumonia and complicated intra-abdominal infections. |
Tygacil Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Nausea | Increased risk of death |
| Vomiting | Pancreatitis |
| Diarrhea | Severe allergic reactions (anaphylaxis) |
| Abdominal pain | Liver problems (jaundice, liver failure) |
| Headache | Clostridium difficile-associated diarrhea (CDAD) |
Tygacil Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Complicated Skin and Skin Structure Infections | 100 mg | 50 mg every 12 hours | Administered intravenously over 30-60 minutes. Treatment duration typically 5-14 days. |
| Complicated Intra-abdominal Infections | 100 mg | 50 mg every 12 hours | Administered intravenously over 30-60 minutes. Treatment duration typically 5-14 days. |
| Community-Acquired Bacterial Pneumonia | 100 mg | 50 mg every 12 hours | Administered intravenously over 30-60 minutes. Treatment duration typically 7-14 days. |
Tygacil Price With And Without Insurance
| Purchase Context | Estimated Price |
|---|---|
| With Insurance | $100 – $300 |
| Without Insurance (U.S.) | $1200 – $2000 |
| From Canada | $851 |
