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General Medication Fact Sheet for Tykerb
| Field | Information |
|---|---|
| Medication Name | Tykerb |
| Generic Name | Lapatinib |
| Boxed/Label Warning | Hepatotoxicity (Liver damage) |
| Purpose | Treatment of HER2-positive breast cancer, in combination with other therapies |
| Mechanism of Action | Inhibits EGFR and HER2 tyrosine kinases, disrupting cancer cell growth |
| Dosage Forms | Oral tablets |
| Available Strengths | 250 mg |
| Dosage Frequency | Typically once daily, or as directed by a healthcare provider |
| Common Side Effects | Diarrhea, nausea, rash, fatigue, vomiting, hand-foot syndrome |
| Serious Side Effects | Hepatotoxicity, decreased left ventricular ejection fraction (LVEF), interstitial lung disease/pneumonitis, severe diarrhea |
| Drug Interactions | CYP3A4 inhibitors (e.g., ketoconazole), CYP3A4 inducers (e.g., rifampin), digoxin, warfarin |
| Important Notes | Monitor liver function, cardiac function, and for signs of lung problems. Take on an empty stomach, at least 1 hour before or 2 hours after a meal. |
| Storage | Store at room temperature away from moisture and light. |
| Missed Dose | If a dose is missed, do not double the next dose. Take the next dose at the regularly scheduled time. |
| Alternatives | Herceptin (trastuzumab), Perjeta (pertuzumab), Kadcyla (ado-trastuzumab emtansine), Nerlynx (neratinib) |
Tykerb Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Herceptin (trastuzumab) | HER2 receptor antagonist | Monoclonal antibody targeting HER2; often used in combination with chemotherapy. |
| Perjeta (pertuzumab) | HER2 receptor antagonist | Another monoclonal antibody that binds to a different site on HER2 than trastuzumab. |
| Kadcyla (ado-trastuzumab emtansine) | HER2-targeted antibody-drug conjugate | Combines trastuzumab with a chemotherapy drug (DM1) for targeted delivery. |
| Nerlynx (neratinib) | Irreversible tyrosine kinase inhibitor | Another oral HER2 inhibitor, used as extended adjuvant therapy after trastuzumab. |
Tykerb Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Diarrhea | Hepatotoxicity (Liver damage) |
| Nausea | Decreased left ventricular ejection fraction (LVEF) |
| Rash | Interstitial lung disease/pneumonitis |
| Fatigue | Severe diarrhea leading to dehydration |
| Vomiting | QT prolongation |
| Hand-foot syndrome (palmar-plantar erythrodysesthesia) | Severe skin reactions |
Tykerb Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| HER2-positive Breast Cancer (with capecitabine) | 1250 mg daily | 1250 mg daily | Take on an empty stomach, at least 1 hour before or 2 hours after a meal. |
| HER2-positive Breast Cancer (with trastuzumab and an aromatase inhibitor) | 1000 mg daily | 1000 mg daily | Take on an empty stomach, at least 1 hour before or 2 hours after a meal. |
Tykerb Price With And Without Insurance
| Purchase Context | Estimated Price |
|---|---|
| With Insurance | $100 – $500 |
| Without Insurance (U.S.) | $6,000 – $7,500 |
| From Canada | $2,735 |
