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Vagifem (Estradiol)
General Medication Fact Sheet for Vagifem
| Field | Information |
|---|---|
| Medication Name | Vagifem |
| Generic Name | Estradiol (as estradiol hemihydrate) |
| Purpose | Treatment of atrophic vaginitis due to menopause. |
| Mechanism of Action | Replaces estrogen locally in the vaginal tissue, reducing symptoms of vaginal atrophy. |
| Dosage Forms | Vaginal Tablets |
| Available Strengths | 10 mcg |
| Dosage Frequency | Initially, one vaginal tablet inserted daily for two weeks, then one vaginal tablet twice a week. |
| Common Side Effects | Vaginal bleeding, vaginal discharge, headache, breast pain. |
| Serious Side Effects | Unusual vaginal bleeding, breast lumps, stroke, blood clots, increased risk of endometrial cancer. |
| Drug Interactions | Estrogens may interact with other hormone therapies, corticosteroids, and certain antibiotics. Consult your doctor or pharmacist. |
| Important Notes | Use with caution in women with a history of blood clots, stroke, heart disease, breast cancer, or uterine cancer. Regular check-ups are recommended. |
| Storage | Store at room temperature away from moisture and heat. |
| Missed Dose | If you miss a dose, use it as soon as you remember. If it is close to your next scheduled dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose. |
| Alternatives | Estrace (estradiol vaginal cream), Imvexxy (estradiol/Bazedoxifene), Premarin (conjugated estrogens vaginal cream), Osphena (ospemifene). |
Vagifem Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Estrace (estradiol vaginal cream) | Estrogen receptor agonist | Vaginal cream containing estradiol to treat vaginal atrophy. |
| Imvexxy (estradiol/bazedoxifene) | Estrogen agonist/estrogen receptor modulator | Combines estrogen with a selective estrogen receptor modulator (SERM). |
| Premarin (conjugated estrogens vaginal cream) | Estrogen receptor agonist | Vaginal cream containing conjugated estrogens to treat vaginal atrophy. |
| Osphena (ospemifene) | Selective Estrogen Receptor Modulator (SERM) | Oral medication that acts like estrogen on the vaginal lining. |
Vagifem Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Vaginal bleeding | Unusual vaginal bleeding |
| Vaginal discharge | Breast lumps |
| Headache | Stroke |
| Breast pain | Blood clots |
| Nausea | Increased risk of endometrial cancer |
Vagifem Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Atrophic Vaginitis | 1 vaginal tablet daily | 1 vaginal tablet twice weekly | Insert one tablet into the vagina using the applicator, preferably at bedtime. |
Vagifem Price With And Without Insurance
| Purchase Context | Estimated Price |
|---|---|
| With Insurance | $25 |
| Without Insurance (U.S.) | $200 – $410 |
| From Canada | $112 |
