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Valcyte (Valganciclovir Hydrochloride)
| Valganciclovir (Generic) Valganciclovir Hydrochloride | ||||||
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Shipped from Canada | ||||||
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Who is the product for? YouOtherAdd Family Member/PetYou must be logged in to add additional members to the order. Don't have an account? or Add Family Member/PetSign inTo continue, please enter your email address and password that you use for your account. | ||||||
| Valganciclovir (Generic) Valganciclovir Hydrochloride | ||||||
|
Shipped from Mauritius | ||||||
| | ||||||
| Select product strength & quantity:
Who is the product for? YouOtherAdd Family Member/PetYou must be logged in to add additional members to the order. Don't have an account? or Add Family Member/PetSign inTo continue, please enter your email address and password that you use for your account. | ||||||
General Medication Fact Sheet for Valcyte
| Field | Information |
|---|---|
| Medication Name | Valcyte |
| Generic Name | Valganciclovir |
| Boxed/Label Warning | Possible hematologic toxicity (neutropenia, anemia, thrombocytopenia), impaired fertility, fetal toxicity, and potential carcinogenicity. Use with caution in women of childbearing potential and men. |
| Purpose | Antiviral medication used to treat cytomegalovirus (CMV) infections, primarily in immunocompromised patients, such as those with HIV/AIDS or transplant recipients. |
| Mechanism of Action | Valganciclovir is a prodrug that is converted to Ganciclovir in the body. Ganciclovir inhibits viral DNA polymerase, thereby preventing viral replication. |
| Dosage Forms | Oral tablets, Oral solution |
| Available Strengths | 450 mg |
| Dosage Frequency | Typically twice daily for induction, then once daily for maintenance, or as directed by a healthcare provider. |
| Common Side Effects | Diarrhea, nausea, vomiting, headache, fatigue, insomnia, fever, cough, abdominal pain. |
| Serious Side Effects | Bone marrow suppression (neutropenia, anemia, thrombocytopenia), kidney problems, liver problems, seizures, infections, visual changes, pancreatitis. |
| Drug Interactions | Probenecid, zidovudine, mycophenolate mofetil, other nephrotoxic drugs (e.g., cyclosporine, amphotericin B). |
| Important Notes | Regular blood tests are required to monitor for bone marrow suppression. Take with food to improve absorption. Adequate hydration is important to prevent kidney problems. |
| Storage | Store at room temperature away from moisture and light. Keep the bottle tightly closed. |
| Missed Dose | Take the missed dose as soon as you remember. If it’s almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to catch up. |
| Alternatives | Ganciclovir, Foscarnet, Cidofovir |
Valcyte Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Ganciclovir | Inhibits viral DNA polymerase. | Available in intravenous and oral formulations. Similar to valganciclovir but requires more frequent dosing or IV administration. |
| Foscarnet | Inhibits viral DNA polymerase. | Alternative antiviral for CMV, often used when resistance to Ganciclovir/valganciclovir develops. Administered intravenously. |
| Cidofovir | Inhibits viral DNA polymerase. | Another antiviral for CMV, administered intravenously. Potential for kidney toxicity requires careful monitoring and pre-hydration. |
Valcyte Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Diarrhea | Bone marrow suppression (neutropenia, anemia, thrombocytopenia) |
| Nausea | Kidney problems |
| Vomiting | Liver problems |
| Headache | Seizures |
| Fatigue | Infections |
| Insomnia | Visual changes |
| Fever | Pancreatitis |
| Cough | Peripheral neuropathy |
| Abdominal Pain | Retinal Detachment (in CMV retinitis patients) |
Valcyte Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| CMV Retinitis (Induction) | 900 mg twice daily | N/A | For 21 days; adjust dose based on kidney function. |
| CMV Retinitis (Maintenance) | N/A | 900 mg once daily | Adjust dose based on kidney function. |
| CMV Prevention in Transplant Recipients | 900 mg once daily | 900 mg once daily | Start within 10 days of transplant and continue for up to 100-200 days; adjust dose based on kidney function. |
Valcyte Price With And Without Insurance
| Purchase Context | Estimated Price |
|---|---|
| With Insurance | $200 |
| Without Insurance (U.S.) | $6700 |
| From Canada | $1750 |
