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General Medication Fact Sheet for Valdoxan
| Field | Information |
|---|---|
| Medication Name | Valdoxan |
| Generic Name | Agomelatine |
| Purpose | Treatment of major depressive disorder in adults |
| Mechanism of Action | Melatonin receptor agonist (MT1 and MT2) and 5-HT2C receptor antagonist |
| Dosage Forms | Oral tablets |
| Available Strengths | 25 mg |
| Dosage Frequency | Typically once daily at bedtime, or as directed by a healthcare provider |
| Common Side Effects | Nausea, dizziness, somnolence, headache |
| Serious Side Effects | Elevated liver enzymes, suicidal thoughts, mania/hypomania |
| Drug Interactions | Fluvoxamine, propranolol, ciprofloxacin, and other CYP1A2 inhibitors |
| Important Notes | Monitor liver function before and during treatment. Avoid alcohol. Report any signs of liver problems or mood changes to your doctor immediately. |
| Storage | Store at room temperature away from moisture and light |
| Missed Dose | Take the missed dose as soon as you remember, unless it is close to your next scheduled dose. In that case, skip the missed dose and continue with your regular dosing schedule. Do not double the dose. |
| Alternatives | Sertraline (Zoloft), Fluoxetine (Prozac), Escitalopram (Lexapro), Citalopram (Celexa) |
Valdoxan Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Sertraline (Zoloft) | Selective serotonin reuptake inhibitor (SSRI) | Commonly used for depression, anxiety, and OCD. |
| Fluoxetine (Prozac) | Selective serotonin reuptake inhibitor (SSRI) | Another common SSRI, also used for bulimia nervosa. |
| Escitalopram (Lexapro) | Selective serotonin reuptake inhibitor (SSRI) | Well-tolerated SSRI, often a first-line treatment for depression. |
| Citalopram (Celexa) | Selective serotonin reuptake inhibitor (SSRI) | Similar to Escitalopram, another SSRI option. |
Valdoxan Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Nausea | Elevated liver enzymes |
| Dizziness | Suicidal thoughts |
| Somnolence (drowsiness) | Mania/hypomania |
| Headache | Allergic reactions (rash, itching, swelling) |
| Anxiety | Significant changes in mood or behavior |
Valdoxan Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Major Depressive Disorder | 25 mg | 25 mg once daily at bedtime; may increase to 50 mg if needed after 2 weeks | Take at bedtime. Monitor liver function. |
