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Vancomycin (Generic)
| Vancocin Vancomycin Hydrochloride | ||||||
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Shipped from Canada | ||||||
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| Select product strength & quantity:
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General Medication Fact Sheet for Vancomycin
| Field | Information |
|---|---|
| Generic Name | Vancomycin |
| Brand Name Versions | Vancocin |
| Boxed/Label Warning | Yes. Nephrotoxicity (kidney damage) and ototoxicity (hearing loss) are potential risks, especially with high doses or concurrent use of other nephrotoxic or ototoxic drugs. |
| Purpose | Antibiotic used to treat serious bacterial infections |
| Mechanism of Action | Inhibits bacterial cell wall synthesis |
| Dosage Forms | Injection, Oral Capsule, Oral Solution |
| Available Strengths | Injection: 500 mg, 750 mg, 1 g, 1.25 g, 1.5 g; Capsules: 125 mg, 250 mg; Oral Solution: 250mg/5mL |
| Dosage Frequency | Typically every 6-12 hours for IV; every 6 hours for oral. Dosage and frequency are highly dependent on the infection type and patient-specific factors. |
| Common Side Effects | Nausea, vomiting, diarrhea, abdominal pain, back pain, headache, infusion-related reactions (Red Man Syndrome) |
| Serious Side Effects | Kidney damage (nephrotoxicity), hearing loss (ototoxicity), low blood pressure, severe allergic reactions, Clostridioides difficile-associated diarrhea (CDAD), Stevens-Johnson Syndrome (SJS) |
| Drug Interactions | Other nephrotoxic drugs (e.g., aminoglycosides, amphotericin B), other ototoxic drugs (e.g., loop diuretics, cisplatin), neuromuscular blocking agents |
| Important Notes | Monitor kidney function and hearing regularly during treatment. Infusion-related reactions can be minimized by slow infusion rates. Report any signs of kidney problems or hearing changes to your doctor immediately. |
| Storage | Store vials at controlled room temperature before reconstitution. After reconstitution, follow the manufacturer’s guidelines for storage and expiration. Capsules should be stored at room temperature. |
| Missed Dose | Contact your doctor for instructions. Do not double the dose. |
| Alternatives | Daptomycin, Linezolid, Ceftaroline, Clindamycin, Metronidazole (for CDAD) |
Vancomycin Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Daptomycin (Cubicin) | Binds to bacterial cell membrane, causing depolarization and cell death | Useful for Gram-positive infections, including those resistant to vancomycin. |
| Linezolid (Zyvox) | Inhibits bacterial protein synthesis | Effective against many Gram-positive bacteria, including vancomycin-resistant strains. |
| Ceftaroline (Teflaro) | Cephalosporin antibiotic that binds to penicillin-binding proteins | Effective against MRSA and other Gram-positive bacteria. |
| Clindamycin (Cleocin) | Inhibits bacterial protein synthesis | Effective against some Gram-positive bacteria and anaerobic bacteria. |
| Metronidazole (Flagyl) | Disrupts DNA and inhibits nucleic acid synthesis | Used primarily for Clostridioides difficile-associated diarrhea (CDAD). |
Vancomycin Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Nausea | Kidney damage (nephrotoxicity) |
| Vomiting | Hearing loss (ototoxicity) |
| Diarrhea | Low blood pressure |
| Abdominal Pain | Severe allergic reactions (anaphylaxis) |
| Infusion-related reactions (Red Man Syndrome) | Clostridioides difficile-associated diarrhea (CDAD) |
| Back Pain | Stevens-Johnson Syndrome (SJS) |
Vancomycin Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| MRSA Pneumonia | 15-20 mg/kg IV | 15-20 mg/kg IV every 8-12 hours | Adjust based on serum trough levels; infuse slowly over at least 60 minutes to avoid Red Man Syndrome. |
| Clostridioides difficile Infection (CDI) | 125 mg orally | 125 mg orally four times daily for 10-14 days | Administer orally; do not inject. |
| Bone and Joint Infections | 15-20 mg/kg IV | 15-20 mg/kg IV every 8-12 hours | Adjust based on serum trough levels; treatment duration varies based on infection severity. |
