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General Medication Fact Sheet for Vastarel MR
| Field | Information |
|---|---|
| Medication Name | Vastarel MR |
| Generic Name | Trimetazidine |
| Purpose | Used to treat angina pectoris (chest pain) |
| Mechanism of Action | Selectively inhibits fatty acid oxidation by inhibiting long-chain 3-ketoacyl-CoA thiolase, which enhances glucose oxidation. |
| Dosage Forms | Modified-release tablets |
| Available Strengths | 35 mg |
| Dosage Frequency | Typically twice daily, or as directed by a healthcare provider |
| Common Side Effects | Dizziness, headache, abdominal pain, nausea, vomiting, dyspepsia |
| Serious Side Effects | Parkinsonian symptoms (tremor, rigidity, slow movement), restless legs syndrome, other movement disorders |
| Drug Interactions | No significant drug interactions reported, but caution should be exercised when co-administered with other antianginal drugs. |
| Important Notes | This medication is not a treatment for acute angina attacks. It is used to prevent angina episodes. |
| Storage | Store at room temperature away from moisture and light. |
| Missed Dose | Take as soon as you remember; skip if it’s almost time for your next dose. Do not double the dose. |
| Alternatives | Beta-blockers (e.g., Metoprolol), Calcium Channel Blockers (e.g., Amlodipine), Nitrates (e.g., Isosorbide Mononitrate), Ranolazine |
Vastarel MR Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Metoprolol (Lopressor, Toprol XL) | Beta-adrenergic blocker | Reduces heart rate and blood pressure, decreasing myocardial oxygen demand. |
| Amlodipine (Norvasc) | Calcium channel blocker | Relaxes blood vessels, improving blood flow and reducing blood pressure. |
| Isosorbide Mononitrate (Imdur) | Nitrate vasodilator | Relaxes blood vessels, increasing blood flow to the heart. |
| Ranolazine (Ranexa) | Inhibits late sodium current in cardiac cells | Helps the heart use energy more efficiently. |
Vastarel MR Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Dizziness | Parkinsonian symptoms (tremor, rigidity, slow movement) |
| Headache | Restless legs syndrome |
| Abdominal pain | Other movement disorders |
Vastarel MR Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Angina Pectoris | 35 mg | 35 mg twice daily | Swallow the tablet whole with a glass of water; do not crush or chew. |
