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General Medication Fact Sheet for Velphoro
| Field | Information |
|---|---|
| Medication Name | Velphoro |
| Generic Name | Sucroferric Oxyhydroxide |
| Purpose | Phosphate binder used to control serum phosphorus levels in patients with chronic kidney disease (CKD) on dialysis. |
| Mechanism of Action | Binds to dietary phosphate in the gastrointestinal tract, forming insoluble complexes that are excreted in the feces, thereby reducing phosphate absorption. |
| Dosage Forms | Chewable tablets |
| Available Strengths | 500 mg |
| Dosage Frequency | Typically taken three times daily with meals, or as directed by a healthcare provider. |
| Common Side Effects | Diarrhea, discolored (dark) feces, nausea, constipation, abdominal pain. |
| Serious Side Effects | Severe gastrointestinal issues (persistent diarrhea, severe constipation), iron overload (rare). |
| Drug Interactions | Levothyroxine (Synthroid), calcium-based supplements, doxycycline, alendronate, some iron supplements. Separate administration times are usually recommended. |
| Important Notes | Must be taken with meals to be effective. Should be chewed completely and not swallowed whole. Consult a doctor or pharmacist regarding potential drug interactions. |
| Storage | Store at room temperature away from moisture and light. |
| Missed Dose | Take the missed dose with your next meal. If it’s close to the time for your next dose, just take that dose with your meal. Do not double the dose. |
| Alternatives | Sevelamer (Renvela, Renagel), Lanthanum Carbonate (Fosrenol), Calcium Acetate, Ferric Citrate (Auryxia) |
Velphoro Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Sevelamer (Renvela, Renagel) | Non-calcium, non-aluminum phosphate binder that binds phosphate in the GI tract. | Available as hydrochloride or carbonate salt. May affect absorption of some medications. |
| Lanthanum Carbonate (Fosrenol) | Dissociates in the acid environment of the upper GI tract and binds phosphate. | Must be chewed thoroughly or crushed before swallowing. |
| Calcium Acetate | Binds to dietary phosphate in the GI tract forming insoluble calcium phosphate salt. | May increase calcium levels; use cautiously in patients with hypercalcemia. |
| Ferric Citrate (Auryxia) | A phosphate binder that also increases iron levels in the body. | May cause discolored feces. |
Velphoro Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Diarrhea | Severe gastrointestinal distress |
| Discolored (dark) feces | Iron overload (rare) |
| Nausea | Signs of allergic reaction (rash, itching, swelling, dizziness, trouble breathing) |
Velphoro Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Hyperphosphatemia in CKD (Dialysis) | 500 mg three times daily | Individualized to maintain target serum phosphorus levels, up to 3000 mg daily. | Take with meals; chew tablet completely. |
Velphoro Price With And Without Insurance
| Purchase Context | Estimated Price |
|---|---|
| With Insurance | $10 |
| Without Insurance (U.S.) | $2100 |
| From CPS | $650 |
