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General Medication Fact Sheet for Vemlidy
| Field | Information |
|---|---|
| Medication Name | Vemlidy |
| Generic Name | Tenofovir Alafenamide |
| Boxed/Label Warning | Lactic acidosis and severe hepatomegaly with steatosis, Post-treatment acute exacerbation of hepatitis B |
| Purpose | Treatment of chronic hepatitis B virus (HBV) infection in adults with compensated liver disease. |
| Mechanism of Action | Inhibits HBV reverse transcriptase, blocking viral replication. It is a prodrug of tenofovir. |
| Dosage Forms | Oral tablets |
| Available Strengths | 25 mg |
| Dosage Frequency | Once daily |
| Common Side Effects | Headache, fatigue, nausea, abdominal pain |
| Serious Side Effects | New or worsening kidney problems, liver problems, lactic acidosis, severe acute exacerbations of hepatitis B |
| Drug Interactions | Certain HIV medications (e.g., protease inhibitors), certain antibiotics (e.g., rifampin), anticonvulsants (e.g., carbamazepine, phenytoin, phenobarbital), St. John’s Wort. |
| Important Notes | Consult your healthcare provider if you have kidney or liver problems. Do not discontinue abruptly without medical advice, as it may lead to acute exacerbation of hepatitis B. |
| Storage | Store at room temperature away from moisture and light. |
| Missed Dose | Take as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose. |
| Alternatives | Baraclude (entecavir), Viread (tenofovir disoproxil fumarate), Hepsera (adefovir dipivoxil), Epivir-HBV (lamivudine) |
Vemlidy Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Baraclude (entecavir) | Inhibits HBV reverse transcriptase. | Another first-line treatment for chronic hepatitis B. |
| Viread (tenofovir disoproxil fumarate) | Inhibits HBV reverse transcriptase. | An older formulation of tenofovir, often associated with more kidney-related side effects compared to Vemlidy. |
| Hepsera (adefovir dipivoxil) | Inhibits HBV DNA polymerase. | Less commonly used as a first-line treatment due to potential side effects. |
| Epivir-HBV (lamivudine) | Inhibits HBV reverse transcriptase. | Can lead to drug resistance, so is usually used in combination with other HBV medications. |
Vemlidy Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Headache | New or worsening kidney problems |
| Fatigue | Liver problems |
| Nausea | Lactic acidosis (symptoms include feeling very weak or tired, unusual muscle pain, trouble breathing, stomach pain with nausea and vomiting, feeling cold, feeling dizzy or lightheaded, or a fast or uneven heart rate) |
| Abdominal pain | Severe acute exacerbations of hepatitis B (if Vemlidy is discontinued) |
| Diarrhea | Bone problems (pain, softening, or thinning) |
Vemlidy Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Chronic Hepatitis B | 25 mg | 25 mg once daily | Take with food. Consult with a healthcare provider for the duration of treatment. |
Vemlidy Price With And Without Insurance
| Purchase Context | Estimated Price |
|---|---|
| With Insurance | $10- $200 |
| Without Insurance (U.S.) | $1800 |
| From Canada | $1200 |
