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General Medication Fact Sheet for Verzenio
| Field | Information |
|---|---|
| Medication Name | Verzenio |
| Generic Name | Abemaciclib |
| Purpose | Used to treat certain types of breast cancer (HR+, HER2-) in adults, often in combination with other medications. |
| Mechanism of Action | Inhibits cyclin-dependent kinases 4 and 6 (CDK4/6), preventing cancer cell growth and division. |
| Dosage Forms | Oral tablets |
| Available Strengths | 50 mg, 100 mg, 150 mg, 200 mg |
| Dosage Frequency | Typically twice daily, approximately 12 hours apart, continuously. |
| Common Side Effects | Diarrhea, nausea, vomiting, fatigue, infections, abdominal pain, decreased appetite, headache, hair thinning/loss. |
| Serious Side Effects | Neutropenia (low white blood cell count), leukopenia (low white blood cell count), anemia, thrombocytopenia (low platelet count), interstitial lung disease (ILD)/pneumonitis, liver problems, blood clots. |
| Drug Interactions | Strong CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin), strong CYP3A4 inducers (e.g., rifampin, phenytoin), CYP3A4 substrates, drugs that cause neutropenia. |
| Important Notes | Take exactly as prescribed; diarrhea is a common side effect and needs to be managed promptly. Monitor blood counts regularly. Report any signs of lung problems (cough, shortness of breath). |
| Storage | Store at room temperature away from moisture and light. Keep out of reach of children. |
| Missed Dose | If you miss a dose, take it as soon as you remember unless it is within 6 hours of your next scheduled dose. Do not take two doses at the same time to make up for a missed dose. |
| Alternatives | Kisqali (ribociclib), Ibrance (palbociclib), Aromasin (exemestane), Letrozole, Tamoxifen |
Verzenio Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Kisqali (ribociclib) | CDK4/6 inhibitor | Another CDK4/6 inhibitor used in combination with an aromatase inhibitor for HR+, HER2- breast cancer. |
| Ibrance (palbociclib) | CDK4/6 inhibitor | Another CDK4/6 inhibitor used in combination with endocrine therapy for HR+, HER2- breast cancer. |
| Aromasin (exemestane) | Aromatase inhibitor | Reduces estrogen levels, used for HR+ breast cancer. |
| Letrozole | Aromatase inhibitor | Reduces estrogen levels, used for HR+ breast cancer. |
| Tamoxifen | Selective estrogen receptor modulator (SERM) | Blocks estrogen receptors in breast tissue. |
Verzenio Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Diarrhea | Neutropenia (low white blood cell count) |
| Nausea | Leukopenia (low white blood cell count) |
| Vomiting | Anemia |
| Fatigue | Thrombocytopenia (low platelet count) |
| Infections | Interstitial lung disease (ILD)/pneumonitis |
| Abdominal pain | Liver problems |
| Decreased appetite | Blood clots (DVT, PE) |
Verzenio Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| HR+, HER2- Breast Cancer (metastatic) | 150 mg twice daily | Adjusted based on tolerability (100 mg or 50 mg twice daily, or discontinue) | Administer continuously with endocrine therapy (e.g., aromatase inhibitor or fulvestrant). Take with or without food. |
| HR+, HER2- Breast Cancer (early stage, high risk) | 150 mg twice daily | Adjusted based on tolerability (100 mg or 50 mg twice daily, or discontinue) | Administer for 2 years, followed by endocrine therapy for a total of 5-10 years. Take with or without food. |
Verzenio Price With And Without Insurance
| Purchase Context | Estimated Price |
|---|---|
| With Insurance | $200 – $700 |
| Without Insurance (U.S.) | $8,700 – $16,300 |
| From Canada | $4,422.30 |
