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General Medication Fact Sheet for Vesanoid
| Field | Information |
|---|---|
| Medication Name | Vesanoid |
| Generic Name | Tretinoin |
| Boxed/Label Warning | Yes, teratogenic and retinoic acid syndrome (APL differentiation syndrome) |
| Purpose | Treatment of acute promyelocytic leukemia (APL) |
| Mechanism of Action | Induces differentiation of promyelocytes to mature cells |
| Dosage Forms | Oral capsules |
| Available Strengths | 10 mg |
| Dosage Frequency | Typically twice daily, or as directed by a healthcare provider |
| Common Side Effects | Headache, fever, weakness, fatigue, mucositis, skin dryness, rash, nausea, vomiting |
| Serious Side Effects | Retinoic acid syndrome (APL differentiation syndrome), leukocytosis, hyperleukocytosis, thrombosis, hemorrhage, increased intracranial pressure |
| Drug Interactions | Ketoconazole, fluconazole, itraconazole, erythromycin, clarithromycin, verapamil, diltiazem, cimetidine, ranitidine, rifampin, pentobarbital, phenobarbital, phenytoin |
| Important Notes | Strict monitoring is required during treatment. Pregnancy must be avoided. Notify your doctor immediately of any signs or symptoms of retinoic acid syndrome. |
| Storage | Store at room temperature away from moisture and light. |
| Missed Dose | Take as soon as you remember; skip if it’s almost time for your next dose. Do not double the dose. Consult your doctor immediately. |
| Alternatives | Arsenic trioxide (Trisenox), Chemotherapy regimens (e.g., daunorubicin and cytarabine), Gemtuzumab ozogamicin (Mylotarg) |
Vesanoid Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Arsenic trioxide (Trisenox) | Induces apoptosis in APL cells | Used as single-agent or in combination with tretinoin for APL treatment. |
| Chemotherapy regimens (e.g., daunorubicin and cytarabine) | Cytotoxic agents that kill rapidly dividing cells | Traditional chemotherapy options for APL, often used in combination. |
| Gemtuzumab ozogamicin (Mylotarg) | Monoclonal antibody targeting CD33, conjugated to a cytotoxic agent | Used in relapsed or refractory APL, targeting CD33-positive cells. |
Vesanoid Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Headache | Retinoic acid syndrome (APL differentiation syndrome) |
| Fever | Leukocytosis/Hyperleukocytosis |
| Weakness | Thrombosis (blood clots) |
| Fatigue | Hemorrhage (bleeding) |
| Mucositis | Increased intracranial pressure |
| Skin dryness | QT prolongation |
Vesanoid Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Acute Promyelocytic Leukemia (APL) | 45 mg/m²/day | 45 mg/m²/day until remission | Administered orally in two divided doses. Consult with a hematologist/oncologist. |
