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Vfend (Voriconazole)
| Voriconazole (Generic) Voriconazole | ||||||
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Shipped from Canada | ||||||
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| Select product strength & quantity:
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General Medication Fact Sheet for Vfend
| Field | Information |
|---|---|
| Medication Name | Vfend |
| Generic Name | Voriconazole |
| Boxed/Label Warning | May cause visual disturbances and hepatotoxicity; potential for serious and fatal adverse reactions. |
| Purpose | Antifungal medication used to treat serious fungal infections. |
| Mechanism of Action | Inhibits fungal cytochrome P450-dependent enzyme 14α-sterol demethylase, blocking ergosterol synthesis. |
| Dosage Forms | Oral tablets, oral suspension, intravenous injection |
| Available Strengths | 50 mg, 200 mg (tablets); 40 mg/mL (oral suspension); 200 mg (injection) |
| Dosage Frequency | Typically twice daily for initial loading doses, then once or twice daily. |
| Common Side Effects | Visual disturbances, nausea, vomiting, abdominal pain, headache, rash. |
| Serious Side Effects | Hepatotoxicity (liver damage), severe skin reactions, visual impairment, arrhythmias, infusion-related reactions. |
| Drug Interactions | CYP450 enzyme inhibitors and inducers, including rifampin, phenytoin, quinidine, efavirenz, and many others. |
| Important Notes | Monitor liver function, electrolyte levels, and visual changes. Avoid prolonged sun exposure. Consult your doctor if you experience any serious side effects. |
| Storage | Store tablets and suspension at room temperature, away from moisture and light. Reconstituted IV solution should be used immediately. |
| Missed Dose | Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double doses. |
| Alternatives | Fluconazole, Itraconazole, Posaconazole, Amphotericin B |
Vfend Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Fluconazole (Diflucan) | Inhibits fungal cytochrome P450 enzyme. | Used for less severe fungal infections. |
| Itraconazole (Sporanox) | Inhibits fungal cytochrome P450 enzyme. | Available in capsules, oral solution, and IV formulation. |
| Posaconazole (Noxafil) | Inhibits fungal cytochrome P450 enzyme. | Broader spectrum than Fluconazole and Itraconazole. |
| Amphotericin B | Binds to ergosterol, disrupting fungal cell membrane. | Often used for severe, life-threatening fungal infections. |
Vfend Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Visual disturbances (blurred vision, altered color perception) | Hepatotoxicity (elevated liver enzymes, jaundice) |
| Nausea | Severe skin reactions (Stevens-Johnson Syndrome, toxic epidermal necrolysis) |
| Vomiting | Visual impairment (optic neuritis, papilledema) |
| Abdominal pain | Arrhythmias (QT prolongation) |
| Headache | Infusion-related reactions (fever, chills, hypotension) |
| Rash | Kidney problems |
Vfend Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Invasive Aspergillosis | 6 mg/kg IV every 12 hours for the first 24 hours, or 400mg orally every 12 hours for the first 24 hours. | 4 mg/kg IV every 12 hours, or 200mg orally every 12 hours. | Adjust based on clinical response and tolerability. Monitor liver function. |
| Candidemia (non-neutropenic) | 6 mg/kg IV every 12 hours for the first 24 hours, or 400mg orally every 12 hours for the first 24 hours. | 4 mg/kg IV every 12 hours, or 200mg orally every 12 hours. | Adjust based on clinical response and tolerability. Monitor liver function. |
| Esophageal Candidiasis | 200 mg orally every 12 hours | 200 mg orally every 12 hours | Duration is typically 14-21 days. |
Vfend Price With And Without Insurance
| Purchase Context | Estimated Price |
|---|---|
| With Insurance | $70 |
| Without Insurance (U.S.) | $7200 |
| From Canada | $500 |
