| Medication Name | Viaderm KC |
| Generic Name | Ketoconazole and Clobetasol Propionate |
| Boxed/Label Warning | Clobetasol propionate is a high-potency topical corticosteroid. Do not use for prolonged periods or large areas. May cause HPA axis suppression, Cushing’s syndrome, hyperglycemia, and glucosuria. Pediatric patients may be more susceptible to systemic toxicity. |
| Purpose | Treatment of fungal skin infections with inflammation. |
| Mechanism of Action | Ketoconazole inhibits the synthesis of ergosterol, a key component of fungal cell membranes. Clobetasol propionate is a high-potency corticosteroid that reduces inflammation by suppressing the migration of polymorphonuclear leukocytes and reversing capillary permeability. |
| Dosage Forms | Topical Cream |
| Available Strengths | Ketoconazole 2% and Clobetasol Propionate 0.05% |
| Dosage Frequency | Apply a thin layer to the affected area twice daily, or as directed by a healthcare provider. |
| Common Side Effects | Burning, itching, irritation, dryness, folliculitis, hypertrichosis, acneiform eruptions, hypopigmentation, secondary infection. |
| Serious Side Effects | HPA axis suppression, Cushing’s syndrome, hyperglycemia, glucosuria, skin atrophy, telangiectasia, striae, systemic absorption of topical corticosteroids. |
| Drug Interactions | Systemic corticosteroids may increase the risk of systemic side effects. Use with occlusive dressings may increase absorption of clobetasol propionate. |
| Important Notes | For topical use only. Avoid contact with eyes. Do not use on broken or infected skin. Do not use for diaper rash. Discontinue if irritation develops. Do not use more than 2 weeks unless directed by a doctor. |
| Storage | Store at room temperature, away from heat and moisture. Keep out of reach of children. |
| Missed Dose | Apply as soon as you remember. If it is almost time for your next dose, skip the missed dose and apply the next dose at the regular time. Do not apply a double dose. |
| Alternatives | Ketoconazole cream, Clobetasol propionate cream, Miconazole, Clotrimazole |