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General Medication Fact Sheet for Videx EC
| Field | Information |
|---|---|
| Medication Name | Videx EC |
| Generic Name | Didanosine |
| Boxed/Label Warning | Lactic acidosis and severe hepatomegaly with steatosis, Pancreatitis, Peripheral Neuropathy |
| Purpose | Antiretroviral medication used in the treatment of HIV-1 infection. |
| Mechanism of Action | Inhibits HIV-1 reverse transcriptase by competing with the natural substrate deoxyadenosine triphosphate and by incorporation into viral DNA, terminating its growth. |
| Dosage Forms | Enteric-coated capsules, Powder for Oral Solution (discontinued) |
| Available Strengths | 125 mg, 200 mg, 250 mg, 400 mg |
| Dosage Frequency | Once daily (for Videx EC), Twice daily (for buffered formulations, now largely discontinued) |
| Common Side Effects | Diarrhea, nausea, vomiting, headache, rash |
| Serious Side Effects | Pancreatitis, peripheral neuropathy, lactic acidosis, liver problems, retinal changes, hyperpigmentation |
| Drug Interactions | Tenofovir, allopurinol, drugs affected by gastric acidity (e.g., ketoconazole), antacids, dapsone, ribavirin |
| Important Notes | Take Videx EC on an empty stomach, 30 minutes before or 2 hours after eating. Monitor for signs of pancreatitis, neuropathy, and lactic acidosis. Regular eye exams are recommended. |
| Storage | Store at room temperature away from moisture and light. Keep the container tightly closed. |
| Missed Dose | Take as soon as you remember, unless it is almost time for your next dose. Do not double the dose. Contact your healthcare provider if you miss several doses. |
| Alternatives | Zidovudine (Retrovir), Lamivudine (Epivir), Abacavir (Ziagen), Emtricitabine (Emtriva) |
Videx EC Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Zidovudine (Retrovir) | Inhibits HIV reverse transcriptase via chain termination. | One of the first antiretroviral drugs; often used in combination therapy. |
| Lamivudine (Epivir) | Inhibits HIV reverse transcriptase via chain termination. | Generally well-tolerated; often used as part of combination therapy. |
| Abacavir (Ziagen) | Inhibits HIV reverse transcriptase via chain termination. | Requires HLA-B*5701 screening due to risk of hypersensitivity reaction. |
| Emtricitabine (Emtriva) | Inhibits HIV reverse transcriptase via chain termination. | Similar to lamivudine; often used in combination therapies such as Truvada or Descovy. |
Videx EC Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Diarrhea | Pancreatitis (abdominal pain, nausea, vomiting) |
| Nausea | Peripheral neuropathy (numbness, tingling, pain in hands and feet) |
| Vomiting | Lactic acidosis (fatigue, muscle pain, difficulty breathing) |
| Headache | Liver problems (jaundice, dark urine) |
| Rash | Retinal changes (vision problems) |
Videx EC Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| HIV-1 Infection (Adults) | 250 mg or 400 mg once daily (based on weight) | 250 mg or 400 mg once daily (based on weight) | Take on an empty stomach, 30 minutes before or 2 hours after eating. |
| HIV-1 Infection (Pediatrics) | Dosage based on weight and age. Consult a healthcare provider. | Dosage based on weight and age. Consult a healthcare provider. | Take on an empty stomach, 30 minutes before or 2 hours after eating. |
Videx EC Price With And Without Insurance
| Purchase Context | Estimated Price |
|---|---|
| With Insurance | $60 |
| Without Insurance (U.S.) | $500 |
| From Canada | $179 |
