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Viekira (Ombitasvir, Paritaprevir, Ritonavir, Dasabuvir)
General Medication Fact Sheet for Viekira
| Field | Information |
|---|---|
| Medication Name | Viekira |
| Generic Name | Ombitasvir/Paritaprevir/Ritonavir/Dasabuvir |
| Boxed/Label Warning | Risk of serious liver injury, mainly in patients with underlying liver disease. |
| Purpose | Treatment of chronic hepatitis C virus (HCV) genotype 1 infection. |
| Mechanism of Action | Ombitasvir inhibits HCV NS5A, paritaprevir inhibits NS3/4A protease, ritonavir boosts paritaprevir levels, and dasabuvir inhibits HCV NS5B polymerase. |
| Dosage Forms | Oral tablets |
| Available Strengths | Ombitasvir/Paritaprevir/Ritonavir 12.5mg/75mg/50mg; Dasabuvir 250mg |
| Dosage Frequency | One ombitasvir/paritaprevir/ritonavir tablet once daily and two dasabuvir tablets twice daily. |
| Common Side Effects | Fatigue, nausea, insomnia, pruritus (itching), asthenia (weakness). |
| Serious Side Effects | Liver failure, hepatitis B virus reactivation, increased ALT levels. |
| Drug Interactions | Strong CYP3A inducers (e.g., rifampin, carbamazepine, phenytoin), ethinyl estradiol-containing medications, certain statins (e.g., simvastatin, lovastatin). Consult a healthcare provider for a complete list. |
| Important Notes | Must be used in combination as directed; do not use if you have severe liver impairment; monitor liver function during treatment; inform your doctor of all medications and supplements you are taking. |
| Storage | Store at room temperature away from moisture and light. |
| Missed Dose | Consult your doctor immediately if you miss a dose. Do not double the dose. |
| Alternatives | Epclusa (sofosbuvir/velpatasvir), Harvoni (ledipasvir/sofosbuvir), Mavyret (glecaprevir/pibrentasvir), Zepatier (elbasvir/grazoprevir) |
Viekira Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Epclusa (sofosbuvir/velpatasvir) | Inhibits HCV NS5A and NS5B | Broadly effective against multiple HCV genotypes. |
| Harvoni (ledipasvir/sofosbuvir) | Inhibits HCV NS5A and NS5B | Effective against HCV genotype 1. |
| Mavyret (glecaprevir/pibrentasvir) | Inhibits HCV NS3/4A protease and NS5A | Pangenotypic, short treatment duration option. |
| Zepatier (elbasvir/grazoprevir) | Inhibits HCV NS5A and NS3/4A protease | Effective against HCV genotypes 1 and 4. |
Viekira Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Fatigue | Liver failure |
| Nausea | Hepatitis B virus reactivation |
| Insomnia | Increased ALT levels |
| Pruritus (itching) | Decompensated Cirrhosis |
| Asthenia (weakness) | Jaundice |
Viekira Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Hepatitis C Genotype 1 (without cirrhosis) | One ombitasvir/paritaprevir/ritonavir tablet and two dasabuvir tablets | Same as starting dose for 12 weeks | Take ombitasvir/paritaprevir/ritonavir once daily and dasabuvir twice daily with meals. |
| Hepatitis C Genotype 1 (with compensated cirrhosis) | One ombitasvir/paritaprevir/ritonavir tablet and two dasabuvir tablets | Same as starting dose for 24 weeks | Take ombitasvir/paritaprevir/ritonavir once daily and dasabuvir twice daily with meals. |
