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General Medication Fact Sheet for Vimizim
| Field | Information |
|---|---|
| Medication Name | Vimizim |
| Generic Name | Elosulfase alfa |
| Purpose | Enzyme replacement therapy for Morquio A syndrome (mucopolysaccharidosis IVA) |
| Mechanism of Action | Provides exogenous N-acetylgalactosamine-6-sulfatase to increase the catabolism of glycosaminoglycans (GAGs) |
| Dosage Forms | Intravenous Infusion |
| Available Strengths | 5 mg/5 mL (1 mg/mL) |
| Dosage Frequency | Once weekly |
| Common Side Effects | Fever, chills, nausea, vomiting, headache, abdominal pain, fatigue, anaphylaxis, injection site reactions (rash, pain, swelling) |
| Serious Side Effects | Anaphylaxis, hypersensitivity reactions |
| Drug Interactions | Unknown significant drug interactions; consult with a healthcare provider |
| Important Notes | Administered via intravenous infusion under the supervision of a healthcare professional. Pre-treatment with antihistamines, antipyretics, and/or corticosteroids is recommended to reduce the risk of infusion reactions. |
| Storage | Store refrigerated at 2°C to 8°C (36°F to 46°F). Do not freeze. Protect from light. |
| Missed Dose | Contact your healthcare provider immediately to reschedule the infusion. |
| Alternatives | There are no direct alternatives that provide the same enzyme replacement. Supportive therapies address specific symptoms and complications of Morquio A syndrome. These include pain management (e.g., ibuprofen, acetaminophen), respiratory support (e.g., oxygen therapy), and orthopedic interventions. |
Vimizim Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Pain Management (e.g., Ibuprofen, Acetaminophen) | Reduces pain and inflammation. | Used to manage pain associated with skeletal abnormalities and joint problems in Morquio A syndrome. |
| Respiratory Support (e.g., Oxygen Therapy) | Provides supplemental oxygen. | Addresses respiratory complications related to skeletal abnormalities and airway obstruction. |
| Orthopedic Interventions (e.g., Spinal Fusion) | Corrects skeletal abnormalities and provides stability. | Manages spinal cord compression and instability. |
Vimizim Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Fever | Anaphylaxis (severe allergic reaction) |
| Chills | Hypersensitivity reactions |
| Nausea | |
| Vomiting | |
| Headache | |
| Abdominal Pain | |
| Fatigue | |
| Injection Site Reactions (rash, pain, swelling) |
Vimizim Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Morquio A Syndrome (MPS IVA) | 2 mg/kg | 2 mg/kg once weekly | Administered as an intravenous infusion over approximately 3-4 hours. Pre-treat with antihistamines, antipyretics, and/or corticosteroids to reduce the risk of infusion reactions. Consult with a qualified healthcare provider for specific administration details. |
Vimizim Price With And Without Insurance
| Purchase Context | Estimated Price |
|---|---|
| With Insurance | $4,000 – $10,000 |
| Without Insurance (U.S.) | $15,000 – $30,000 |
| From Canada | Not Available for Import |
