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General Medication Fact Sheet for Vimovo
| Field | Information |
|---|---|
| Medication Name | Vimovo |
| Generic Name | Naproxen and Esomeprazole |
| Boxed/Label Warning | NSAIDs may increase the risk of serious cardiovascular thrombotic events, myocardial infarction, and stroke, which can be fatal. NSAIDs also increase the risk of serious gastrointestinal adverse events including bleeding, ulceration, and perforation of the stomach or intestines, which can be fatal. |
| Purpose | Used to relieve the symptoms of arthritis (osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis) and to decrease the risk of developing stomach ulcers in people who are taking naproxen. |
| Mechanism of Action | Naproxen reduces pain and inflammation by inhibiting prostaglandin synthesis. Esomeprazole reduces gastric acid secretion, protecting the stomach lining. |
| Dosage Forms | Oral tablets |
| Available Strengths | Naproxen 500 mg / Esomeprazole 20 mg |
| Dosage Frequency | Typically twice daily, at least 30 minutes before meals. |
| Common Side Effects | Heartburn, indigestion, abdominal pain, constipation, diarrhea, nausea. |
| Serious Side Effects | Increased risk of heart attack or stroke, gastrointestinal bleeding, kidney problems, liver problems, allergic reactions, symptoms of lupus. |
| Drug Interactions | Aspirin, anticoagulants (e.g., warfarin), clopidogrel, SSRIs, SNRIs, ACE inhibitors, diuretics, methotrexate, certain antifungals (e.g., ketoconazole). |
| Important Notes | Take at least 30 minutes before meals. Inform your doctor if you have a history of heart problems, stomach ulcers, or kidney/liver disease. Do not take with other NSAIDs. |
| Storage | Store at room temperature away from moisture and light. |
| Missed Dose | Take as soon as you remember, unless it is almost time for your next dose. Do not double the dose. |
| Alternatives | Naproxen with a separate proton pump inhibitor (PPI) like omeprazole, Celecoxib, Meloxicam, Ibuprofen with a PPI. |
Vimovo Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Naproxen + Omeprazole | Naproxen inhibits prostaglandin synthesis; Omeprazole reduces stomach acid. | Individual components of Vimovo taken separately. |
| Celecoxib (Celebrex) | Selective COX-2 inhibitor | NSAID with potentially lower risk of gastrointestinal side effects, but may require a separate PPI if stomach protection is needed. |
| Meloxicam (Mobic) | Selective COX-2 inhibitor | Another NSAID option, but may still require a separate PPI. |
| Ibuprofen (Advil, Motrin) + Omeprazole | Ibuprofen inhibits prostaglandin synthesis; Omeprazole reduces stomach acid. | Combination of a different NSAID with a PPI. |
Vimovo Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Heartburn | Increased risk of heart attack or stroke |
| Indigestion | Gastrointestinal bleeding |
| Abdominal pain | Kidney problems |
| Constipation | Liver problems |
| Diarrhea | Allergic reactions (rash, itching, swelling, difficulty breathing) |
| Nausea | Symptoms of lupus |
Vimovo Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Osteoarthritis | One tablet | One tablet twice daily | Take at least 30 minutes before meals. |
| Rheumatoid Arthritis | One tablet | One tablet twice daily | Take at least 30 minutes before meals. |
| Ankylosing Spondylitis | One tablet | One tablet twice daily | Take at least 30 minutes before meals. |
Vimovo Price With And Without Insurance
| Purchase Context | Estimated Price |
|---|---|
| With Insurance | $35 |
| Without Insurance (U.S.) | $400 |
| From Canada | $125 |
