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General Medication Fact Sheet for Vitrase
| Field | Information |
|---|---|
| Medication Name | Vitrase |
| Generic Name | Hyaluronidase |
| Purpose | Enzyme used to increase the absorption and dispersion of other injected drugs; also used to promote the absorption of excess fluids and blood in the tissues. |
| Mechanism of Action | Hydrolyzes hyaluronic acid, a polysaccharide found in the extracellular matrix, thereby decreasing its viscosity and increasing tissue permeability. |
| Dosage Forms | Injectable solution |
| Available Strengths | 200 Units/mL |
| Dosage Frequency | Varies based on the specific application and agent being used. Administered by a healthcare professional. |
| Common Side Effects | Injection site reactions (pain, redness, swelling), itching |
| Serious Side Effects | Allergic reactions (rash, hives, difficulty breathing), angioedema |
| Drug Interactions | May affect the absorption of other locally administered drugs. Use with caution with dopamine and/or alpha agonists. |
| Important Notes | Administered by a healthcare professional. Monitor for signs of allergic reaction. |
| Storage | Store refrigerated at 2° to 8°C (36° to 46°F). Protect from light. |
| Missed Dose | Not applicable, as it is administered by a healthcare professional in a clinical setting. |
| Alternatives | Hylenex (hyaluronidase), Wydase (hyaluronidase) |
Vitrase Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Hylenex (hyaluronidase) | Hydrolyzes hyaluronic acid | Used as an adjuvant to increase the absorption and dispersion of injected drugs. |
| Wydase (hyaluronidase) | Hydrolyzes hyaluronic acid | Similar to Vitrase; facilitates the absorption of fluids and medications. |
Vitrase Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Injection site reactions (pain, redness, swelling) | Allergic reactions (rash, hives, difficulty breathing) |
| Itching | Angioedema (swelling of the face, lips, tongue, or throat) |
| Headache | Rarely, systemic reactions |
Vitrase Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Facilitating Subcutaneous or Intramuscular Drug Absorption | 150 Units | N/A | Added to or injected at the same site as the primary medication. |
| Hypodermoclysis (Subcutaneous Fluid Administration) | 150 Units | N/A | Injected into the subcutaneous tissue before initiating fluid administration. |
| Promoting Absorption of Hematoma/Extravasated Fluid | Variable | N/A | Dosage and frequency determined by the extent of fluid accumulation; consult with a healthcare professional. |
