Notice: Images are for illustration only and may not reflect the exact product you receive. Brand-name medications may look different depending on their country of origin—Canadian versions, for example, often include a "PR" symbol on the packaging. Rest assured, the medication, dosage, and active ingredients will be exactly as prescribed. Canada Pharmacy Store is committed to your health and safety, and we work only with licensed pharmacies to ensure you receive trusted, high-quality medication every time.
Voriconazole (Generic)
| Vfend Voriconazole | ||||||
Shipped from United Kingdom | ||||||
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| Vfend Voriconazole | ||||||
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Shipped from Mauritius | ||||||
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| Vfend Injection Voriconazole | ||||||
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Shipped from Canada | ||||||
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General Medication Fact Sheet for Voriconazole
| Field | Information |
|---|---|
| Generic Name | Voriconazole |
| Brand Name Versions | Vfend |
| Boxed/Label Warning | QTc Prolongation, Hepatotoxicity, Infusion-Related Reactions |
| Purpose | Antifungal medication used to treat serious fungal infections |
| Mechanism of Action | Inhibits fungal cytochrome P450, blocking the synthesis of ergosterol, a crucial component of the fungal cell membrane |
| Dosage Forms | Oral tablets, oral suspension, intravenous injection |
| Available Strengths | 50 mg, 200 mg (tablets); 200 mg/5 mL (oral suspension) |
| Dosage Frequency | Typically twice daily for the initial loading dose, then once or twice daily for maintenance, as directed by a healthcare provider |
| Common Side Effects | Visual disturbances (blurred vision, changes in color vision), nausea, vomiting, abdominal pain, headache |
| Serious Side Effects | Liver problems (hepatotoxicity), heart rhythm changes (QTc prolongation), severe skin reactions (Stevens-Johnson syndrome), visual disturbances, kidney problems |
| Drug Interactions | Many significant interactions; azole antifungals, rifampin, phenytoin, carbamazepine, quinidine, sirolimus, statins, warfarin and many others. Consult your pharmacist or doctor. |
| Important Notes | Use caution while driving or operating machinery due to visual disturbances; monitor liver function regularly; avoid prolonged sun exposure; report any signs of liver problems or allergic reactions immediately |
| Storage | Store tablets and oral suspension at room temperature away from moisture and light. Follow specific storage instructions for intravenous solutions. |
| Missed Dose | Take the missed dose as soon as you remember. If it’s almost time for the next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose. |
| Alternatives | Fluconazole, Itraconazole, Posaconazole, Amphotericin B |
Voriconazole Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Fluconazole (Diflucan) | Inhibits fungal cytochrome P450 | Less broad spectrum than voriconazole; often used for yeast infections. |
| Itraconazole (Sporanox) | Inhibits fungal cytochrome P450 | Broader spectrum than Fluconazole, but narrower than voriconazole. |
| Posaconazole (Noxafil) | Inhibits fungal cytochrome P450 | Broad-spectrum antifungal, often used in immunocompromised patients. |
| Amphotericin B | Binds to ergosterol, disrupting fungal cell membrane | Potent antifungal, often reserved for severe infections due to its toxicity. |
Voriconazole Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Visual disturbances (blurred vision, changes in color vision) | Liver problems (hepatotoxicity) |
| Nausea | Heart rhythm changes (QTc prolongation) |
| Vomiting | Severe skin reactions (Stevens-Johnson syndrome) |
| Abdominal pain | Kidney problems |
| Headache | Allergic reactions (rash, itching, swelling, difficulty breathing) |
Voriconazole Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Invasive Aspergillosis | 6 mg/kg IV every 12 hours for the first 24 hours; or 400 mg orally every 12 hours for the first 24 hours | 4 mg/kg IV every 12 hours; or 200 mg orally every 12 hours | IV dose should be infused over 1-2 hours. Oral dose should be taken at least one hour before or one hour after meals. |
| Candidemia (in patients without neutropenia) | 6 mg/kg IV every 12 hours for the first 24 hours; or 400 mg orally every 12 hours for the first 24 hours | 4 mg/kg IV every 12 hours; or 200 mg orally every 12 hours | IV dose should be infused over 1-2 hours. Oral dose should be taken at least one hour before or one hour after meals. |
| Esophageal Candidiasis | N/A | 200 mg orally every 12 hours | Oral dose should be taken at least one hour before or one hour after meals. |
Voriconazole Price With And Without Insurance
| Purchase Context | Estimated Price |
|---|---|
| With Insurance | $20 – $100 |
| Without Insurance (U.S.) | $250 – $350 |
| From Canada | $110 (depending on dosage and quantity) |