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General Medication Fact Sheet for Votrient
| Field | Information |
|---|---|
| Medication Name | Votrient |
| Generic Name | Pazopanib |
| Boxed/Label Warning | VOTRIENT can cause severe and fatal hepatotoxicity. Monitor hepatic function. Interrupt, reduce the dose, or discontinue based on severity. |
| Purpose | Tyrosine kinase inhibitor used to treat advanced renal cell carcinoma (RCC), advanced soft tissue sarcoma (STS), and epithelial ovarian cancer. |
| Mechanism of Action | Inhibits multiple receptor tyrosine kinases (RTKs) involved in tumor growth and angiogenesis, including VEGFR-1, -2, and -3, PDGFR-α and -β, and c-Kit. |
| Dosage Forms | Oral tablets |
| Available Strengths | 200 mg |
| Dosage Frequency | Typically once daily, without food, or as directed by a healthcare provider. |
| Common Side Effects | Diarrhea, fatigue, hypertension, hair color changes, nausea, anorexia. |
| Serious Side Effects | Hepatotoxicity, QT prolongation, arterial thromboembolic events, venous thromboembolic events, hemorrhage, gastrointestinal perforation and fistula, hypertension, posterior reversible encephalopathy syndrome (PRES), hypothyroidism, proteinuria, wound healing complications. |
| Drug Interactions | CYP3A4 inhibitors and inducers, drugs that raise gastric pH, drugs known to prolong the QT interval. |
| Important Notes | Take without food (at least 1 hour before or 2 hours after a meal). Monitor liver function regularly. Avoid grapefruit and grapefruit juice. |
| Storage | Store at room temperature away from moisture and light. |
| Missed Dose | If a dose is missed, it should not be taken if the next dose is due within 12 hours. Otherwise, the missed dose should be taken as soon as the patient remembers. |
| Alternatives | Sutent (sunitinib), Cabometyx (cabozantinib), Inlyta (axitinib), Lenvima (lenvatinib) |
Votrient Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Sutent (sunitinib) | Tyrosine kinase inhibitor targeting VEGFR, PDGFR, c-KIT, FLT3, and RET | Another tyrosine kinase inhibitor used for RCC and other cancers. |
| Cabometyx (cabozantinib) | Tyrosine kinase inhibitor targeting VEGFR, MET, AXL, and RET | Another tyrosine kinase inhibitor used for RCC and other cancers. |
| Inlyta (axitinib) | Selective VEGF receptor tyrosine kinase inhibitor | Used in combination with other medications for RCC. |
| Lenvima (lenvatinib) | Tyrosine kinase inhibitor targeting VEGFR, FGFR, RET, and KIT | Used in combination with everolimus for RCC. |
Votrient Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Diarrhea | Hepatotoxicity (liver damage) |
| Fatigue | QT prolongation (irregular heartbeat) |
| Hypertension (high blood pressure) | Arterial thromboembolic events (stroke, heart attack) |
| Hair color changes | Venous thromboembolic events (blood clots) |
| Nausea | Hemorrhage (bleeding) |
| Anorexia | Gastrointestinal perforation and fistula |
| Skin rash | Posterior Reversible Encephalopathy Syndrome (PRES) |
Votrient Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Advanced Renal Cell Carcinoma (RCC) | 800 mg once daily | Adjusted based on individual tolerability, may range from 200 mg to 800 mg daily | Take without food (at least 1 hour before or 2 hours after a meal). |
| Advanced Soft Tissue Sarcoma (STS) | 800 mg once daily | Adjusted based on individual tolerability, may range from 200 mg to 800 mg daily | Take without food (at least 1 hour before or 2 hours after a meal). |
| Epithelial Ovarian Cancer | 400mg once daily | Adjusted based on individual tolerability | Take without food (at least 1 hour before or 2 hours after a meal). In combination with weekly paclitaxel. |
Votrient Price With And Without Insurance
| Purchase Context | Estimated Price |
|---|---|
| With Insurance | $50 – $200 |
| Without Insurance (U.S.) | $11000 |
| From CPS | $700 |
