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General Medication Fact Sheet for Vraylar
| Field | Information |
|---|---|
| Medication Name | Vraylar |
| Generic Name | Cariprazine |
| Boxed/Label Warning | Increased risk of death in elderly patients with dementia-related psychosis; increased risk of suicidal thoughts and behaviors in young adults and children. |
| Purpose | Treatment of schizophrenia, bipolar I disorder (manic or mixed episodes), and bipolar depression. |
| Mechanism of Action | Atypical antipsychotic; partial agonist activity at dopamine D2 and D3 receptors, and serotonin 5-HT1A receptors, and antagonist activity at serotonin 5-HT2A receptors. |
| Dosage Forms | Oral capsules |
| Available Strengths | 1.5 mg, 3 mg, 4.5 mg, 6 mg |
| Dosage Frequency | Once daily |
| Common Side Effects | Akathisia (restlessness), extrapyramidal symptoms (EPS), tremor, dyspepsia, vomiting, somnolence, and blurred vision. |
| Serious Side Effects | Neuroleptic Malignant Syndrome (NMS), tardive dyskinesia, metabolic changes (hyperglycemia, dyslipidemia, weight gain), orthostatic hypotension, and suicidal thoughts/behaviors. |
| Drug Interactions | Strong CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin), strong CYP3A4 inducers (e.g., rifampin, carbamazepine), other centrally acting drugs. |
| Important Notes | Monitor for changes in mental status, suicidal thoughts/behaviors, and metabolic parameters. Use caution in patients with cardiovascular disease or conditions that would predispose them to hypotension. |
| Storage | Store at room temperature away from moisture and light. |
| Missed Dose | Take the missed dose as soon as you remember. If it is close to your next scheduled dose, skip the missed dose and take your next dose at the regular time. Do not double the dose. |
| Alternatives | Risperidone (Risperdal), Quetiapine (Seroquel), Aripiprazole (Abilify), Lurasidone (Latuda) |
Vraylar Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Risperidone (Risperdal) | Atypical antipsychotic; dopamine D2 and serotonin 5-HT2A receptor antagonist. | Available in oral and injectable forms. |
| Quetiapine (Seroquel) | Atypical antipsychotic; antagonist at multiple receptors, including dopamine D1, D2, serotonin 5-HT1A, 5-HT2A, histamine H1, and adrenergic α1 and α2 receptors. | May cause sedation; useful for sleep disturbances. |
| Aripiprazole (Abilify) | Atypical antipsychotic; partial agonist at dopamine D2 and serotonin 5-HT1A receptors, and antagonist at serotonin 5-HT2A receptors. | Lower risk of weight gain compared to some other antipsychotics. |
| Lurasidone (Latuda) | Atypical antipsychotic; antagonist at dopamine D2 and serotonin 5-HT2A and 5-HT7 receptors. | Should be taken with at least 350 calories of food. |
Vraylar Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Akathisia (restlessness) | Neuroleptic Malignant Syndrome (NMS) |
| Extrapyramidal Symptoms (EPS) | Tardive Dyskinesia |
| Tremor | Metabolic Changes (Hyperglycemia, Dyslipidemia, Weight Gain) |
| Dyspepsia | Orthostatic Hypotension |
| Vomiting | Suicidal Thoughts/Behaviors |
| Somnolence | Increased risk of death in elderly patients with dementia-related psychosis |
| Blurred Vision |
Vraylar Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Schizophrenia | 1.5 mg once daily | 1.5 to 6 mg once daily (adjust based on response and tolerability) | Administer orally once daily, with or without food. |
| Bipolar I Disorder (Manic or Mixed Episodes) | 3 mg once daily | 3 to 6 mg once daily (adjust based on response and tolerability) | Administer orally once daily, with or without food. |
| Bipolar Depression | 1.5 mg once daily | 1.5 to 3 mg once daily (adjust based on response and tolerability) | Administer orally once daily, with or without food. |
Vraylar Price With And Without Insurance
| Purchase Context | Estimated Price |
|---|---|
| With Insurance | $20 – $100 |
| Without Insurance (U.S.) | $1200 |
| From Canada | $235 |
