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Vytorin (Ezetimibe, Simvastatin)
| Etalize-S (Generic) Ezetimibe, Simvastatin | ||||||
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Shipped from Mauritius | ||||||
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| Select product strength & quantity:
Who is the product for? YouOtherAdd Family Member/PetYou must be logged in to add additional members to the order. Don't have an account? or Add Family Member/PetSign inTo continue, please enter your email address and password that you use for your account. | ||||||
| Select product strength & quantity:
Who is the product for? YouOtherAdd Family Member/PetYou must be logged in to add additional members to the order. Don't have an account? or Add Family Member/PetSign inTo continue, please enter your email address and password that you use for your account. | ||||||
| Select product strength & quantity:
Who is the product for? YouOtherAdd Family Member/PetYou must be logged in to add additional members to the order. Don't have an account? or Add Family Member/PetSign inTo continue, please enter your email address and password that you use for your account. | ||||||
General Medication Fact Sheet for Vytorin
| Field | Information |
|---|---|
| Medication Name | Vytorin |
| Generic Name | Ezetimibe/Simvastatin |
| Boxed/Label Warning | Increased risk of myopathy/rhabdomyolysis, particularly at higher Simvastatin doses. |
| Purpose | Lowers LDL cholesterol and triglycerides while raising HDL cholesterol. |
| Mechanism of Action | Ezetimibe inhibits intestinal absorption of cholesterol; Simvastatin inhibits HMG-CoA reductase, a rate-limiting enzyme in cholesterol synthesis. |
| Dosage Forms | Oral tablets |
| Available Strengths | Ezetimibe 10 mg/Simvastatin 10 mg, Ezetimibe 10 mg/Simvastatin 20 mg, Ezetimibe 10 mg/Simvastatin 40 mg, Ezetimibe 10 mg/Simvastatin 80 mg |
| Dosage Frequency | Once daily in the evening |
| Common Side Effects | Muscle pain, tenderness, or weakness; headache; upper respiratory tract infection. |
| Serious Side Effects | Rhabdomyolysis (muscle breakdown); liver problems; allergic reactions; myopathy. |
| Drug Interactions | Other statins, fibrates (e.g., gemfibrozil), niacin, cyclosporine, certain antibiotics (e.g., erythromycin, clarithromycin), antifungals (e.g., itraconazole, ketoconazole), HIV protease inhibitors, grapefruit juice. |
| Important Notes | Report any unexplained muscle pain, tenderness, or weakness to your doctor immediately. Avoid consuming large quantities of grapefruit juice. Regular liver function tests may be required. |
| Storage | Store at room temperature away from moisture and light. |
| Missed Dose | Take as soon as you remember; skip if it’s almost time for your next dose. Do not double the dose. |
| Alternatives | Ezetimibe (Zetia), Simvastatin (Zocor), Atorvastatin (Lipitor), Rosuvastatin (Crestor). |
Vytorin Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Ezetimibe (Zetia) | Inhibits intestinal absorption of cholesterol | Reduces LDL cholesterol by blocking absorption in the small intestine. |
| Simvastatin (Zocor) | HMG-CoA reductase inhibitor (statin) | Reduces cholesterol production in the liver. |
| Atorvastatin (Lipitor) | HMG-CoA reductase inhibitor (statin) | More potent statin for lowering LDL cholesterol. |
| Rosuvastatin (Crestor) | HMG-CoA reductase inhibitor (statin) | Most potent statin; effective for aggressive LDL reduction. |
| Praluent (alirocumab) | PCSK9 inhibitor | For patients who need further LDL lowering, often used when statins are not enough. |
Vytorin Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Muscle pain, tenderness, or weakness | Rhabdomyolysis (muscle breakdown) |
| Headache | Liver problems (elevated liver enzymes) |
| Upper respiratory tract infection | Allergic reactions (rash, itching, swelling, difficulty breathing) |
| Diarrhea | Myopathy (muscle disease) |
| Nausea | Memory loss or confusion |
Vytorin Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| High Cholesterol (Heterozygous Familial Hypercholesterolemia) | Ezetimibe 10 mg/Simvastatin 10 mg or 20 mg | Ezetimibe 10 mg/Simvastatin 10 mg to 40 mg (max 80mg) | Take once daily in the evening. Adjust dose based on LDL-C levels and tolerability. |
| High Cholesterol (Non-Familial Hypercholesterolemia) | Ezetimibe 10 mg/Simvastatin 10 mg or 20 mg | Ezetimibe 10 mg/Simvastatin 10 mg to 40 mg (max 80mg) | Take once daily in the evening. Adjust dose based on LDL-C levels and tolerability. |
| Homozygous Familial Hypercholesterolemia | Individualized by physician | Individualized by physician | Used in conjunction with other lipid-lowering treatments. |
Vytorin Price With And Without Insurance
| Purchase Context | Estimated Price |
|---|---|
| With Insurance | $30 |
| Without Insurance (U.S.) | $250 – $350 |
| From CPS | $99 |
