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General Medication Fact Sheet for Vyzulta
| Field | Information |
|---|---|
| Medication Name | Vyzulta |
| Generic Name | Latanoprostene bunod |
| Purpose | To lower intraocular pressure (IOP) in patients with open-angle glaucoma or ocular hypertension. |
| Mechanism of Action | Dual mechanism: Latanoprost acid increases uveoscleral outflow, and butanediol mononitrate releases nitric oxide, increasing trabecular meshwork outflow. |
| Dosage Forms | Ophthalmic solution (eye drops) |
| Available Strengths | 0.024% |
| Dosage Frequency | Once daily in the evening |
| Common Side Effects | Eye redness, eye irritation, eye pain, blurred vision, foreign body sensation, increased lacrimation. |
| Serious Side Effects | Eyelid skin darkening, increased brown pigmentation of the iris, growth of eyelashes, macular edema. |
| Drug Interactions | Use of more than one prostaglandin analog may decrease the intraocular pressure lowering effect. |
| Important Notes | Remove contact lenses before administration and wait at least 15 minutes before reinserting. May cause permanent changes to eye color. |
| Storage | Store in the original container at refrigerated temperatures 2° to 8°C (36° to 46°F) until opened. After opening, the bottle may be kept at room temperature up to 25°C (77°F) for 8 weeks. |
| Missed Dose | If a dose is missed, administer the drop as soon as remembered. If it is almost time for the next dose, skip the missed dose and administer the next dose at the regular time. Do not double the dose. |
| Alternatives | Latanoprost, Travoprost, Bimatoprost, Timolol |
Vyzulta Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Latanoprost (Xalatan) | Prostaglandin analog; increases uveoscleral outflow. | Commonly used first-line treatment. |
| Travoprost (Travatan Z) | Prostaglandin analog; increases uveoscleral outflow. | Similar efficacy to Latanoprost. |
| Bimatoprost (Lumigan) | Prostamide analog; increases uveoscleral outflow. | May cause more eyelash growth. |
| Timolol (Timoptic) | Beta-adrenergic receptor blocker; decreases aqueous humor production. | May have systemic side effects. |
Vyzulta Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Eye redness | Eyelid skin darkening |
| Eye irritation | Increased brown pigmentation of the iris |
| Eye pain | Growth of eyelashes |
| Blurred vision | Macular edema |
| Foreign body sensation | Iritis or uveitis |
Vyzulta Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Open-Angle Glaucoma | One drop | One drop daily | Administer in the affected eye(s) once daily in the evening. |
| Ocular Hypertension | One drop | One drop daily | Administer in the affected eye(s) once daily in the evening. |
Vyzulta Price With And Without Insurance
| Purchase Context | Estimated Price |
|---|---|
| With Insurance | $75 |
| Without Insurance (U.S.) | $500 |
| From Canada | $100 |
