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General Medication Fact Sheet for Wakix
| Field | Information |
|---|---|
| Medication Name | Wakix |
| Generic Name | Pitolisant |
| Purpose | To treat excessive daytime sleepiness (EDS) in adults with narcolepsy. |
| Mechanism of Action | Histamine-3 (H3) receptor antagonist/inverse agonist, increasing histamine release in the brain. |
| Dosage Forms | Oral tablets |
| Available Strengths | 4.45 mg, 17.8 mg |
| Dosage Frequency | Once daily, in the morning. |
| Common Side Effects | Headache, insomnia, nausea, anxiety, irritability |
| Serious Side Effects | QT prolongation, psychiatric adverse reactions (e.g., depression, psychosis) |
| Drug Interactions | Strong CYP2D6 inhibitors, CYP3A4 inducers, drugs that prolong the QT interval |
| Important Notes | Monitor for psychiatric symptoms and QT prolongation. Avoid use with other QT-prolonging drugs. |
| Storage | Store at room temperature away from moisture and light. |
| Missed Dose | Take as soon as you remember that day. If you miss a dose, do not double the dose the next day. |
| Alternatives | Modafinil, Armodafinil, Solriamfetol, Amphetamine/Dextroamphetamine |
Wakix Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Modafinil (Provigil) | Dopamine reuptake inhibitor | Promotes wakefulness. May have a risk of psychiatric side effects. |
| Armodafinil (Nuvigil) | Dopamine reuptake inhibitor | R-enantiomer of Modafinil, with a longer half-life. |
| Solriamfetol (Sunosi) | Dopamine and norepinephrine reuptake inhibitor | Promotes wakefulness; may increase blood pressure. |
| Amphetamine/Dextroamphetamine (Adderall) | Releases dopamine and norepinephrine | Stimulant medication; potential for abuse and dependence. |
Wakix Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Headache | QT prolongation |
| Insomnia | Psychiatric adverse reactions (e.g., depression, psychosis) |
| Nausea | Severe allergic reactions |
| Anxiety | Cardiac arrhythmias |
| Irritability | Suicidal thoughts or behavior |
Wakix Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Narcolepsy | 8.9 mg once daily | 17.8 mg to 35.6 mg once daily | Administer in the morning. Dosage adjustments based on response and tolerability. |
Wakix Price With And Without Insurance
| Purchase Context | Estimated Price |
|---|---|
| With Insurance | $300 |
| Without Insurance (U.S.) | $1700 |
| From Canada | $820 |
