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General Medication Fact Sheet for Wegovy
| Field | Information |
|---|---|
| Medication Name | Wegovy |
| Generic Name | Semaglutide |
| Boxed/Label Warning | Possible risk of thyroid C-cell tumors, including medullary thyroid carcinoma (MTC). Avoid use in patients with a personal or family history of MTC or in patients with Multiple Endocrine Neoplasia syndrome type 2 (MEN 2). |
| Purpose | Chronic weight management in adults and adolescents with obesity or overweight with at least one weight-related condition, used with a reduced calorie diet and increased physical activity. |
| Mechanism of Action | GLP-1 receptor agonist, which increases insulin release, decreases glucagon secretion, and slows gastric emptying, leading to reduced appetite and calorie intake. |
| Dosage Forms | Subcutaneous injection |
| Available Strengths | 0.25 mg, 0.5 mg, 1 mg, 1.7 mg, 2.4 mg |
| Dosage Frequency | Once weekly |
| Common Side Effects | Nausea, diarrhea, vomiting, constipation, abdominal pain, headache, fatigue. |
| Serious Side Effects | Pancreatitis, gallbladder problems, kidney problems, increased heart rate, suicidal thoughts, allergic reactions. |
| Drug Interactions | Insulin secretagogues (e.g., sulfonylureas), insulin, oral medications (due to delayed gastric emptying). |
| Important Notes | Use with caution in patients with a history of pancreatitis or gallbladder disease. Monitor for depression or suicidal thoughts. Inform your healthcare provider of all medications and supplements you are taking. |
| Storage | Store refrigerated at 2°C to 8°C (36°F to 46°F) in the original carton to protect from light. Do not freeze. If needed, Wegovy can be stored at room temperature (up to 30°C/86°F) for a maximum of 28 days. |
| Missed Dose | Administer as soon as possible within 5 days of the missed dose. If more than 5 days have passed, skip the missed dose and administer the next dose on the regularly scheduled day. |
| Alternatives | Ozempic (semaglutide), Saxenda (liraglutide), Mounjaro (tirzepatide), Contrave (naltrexone/bupropion) |
Wegovy Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Ozempic (semaglutide) | GLP-1 receptor agonist | Also contains semaglutide but is primarily indicated for type 2 diabetes. |
| Saxenda (liraglutide) | GLP-1 receptor agonist | Another injectable GLP-1 receptor agonist approved for weight loss. |
| Mounjaro (tirzepatide) | GIP and GLP-1 receptor agonist | Dual-acting incretin mimetic for weight management and type 2 diabetes. |
| Contrave (naltrexone/bupropion) | Combination of opioid antagonist and antidepressant | Oral medication that affects brain areas involved in appetite regulation. |
Wegovy Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Nausea | Pancreatitis |
| Diarrhea | Gallbladder problems (e.g., gallstones, cholecystitis) |
| Vomiting | Kidney problems |
| Constipation | Increased heart rate |
| Abdominal pain | Hypoglycemia (especially if used with insulin secretagogues or insulin) |
| Headache | Suicidal thoughts or behavior |
| Fatigue | Allergic reactions (rash, itching, swelling, difficulty breathing) |
Wegovy Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Chronic Weight Management | 0.25 mg once weekly | Target maintenance dose is 2.4 mg once weekly, but increase gradually based on tolerance. | Administer subcutaneously in the abdomen, thigh, or upper arm. Rotate injection sites. |
Wegovy Price With And Without Insurance
| Purchase Context | Estimated Price |
|---|---|
| With Insurance | $25 – $250 |
| Without Insurance (U.S.) | $1300 – 1800 |
| From Canada | $600 |




