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Wellbutrin (Bupropion)
| Bupron XL (Generic) Bupropion HCl | ||||||
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Shipped from Mauritius | ||||||
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| Bupropion XL (Generic) Bupropion Hydrochloride XL | ||||||
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Shipped from Canada | ||||||
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Who is the product for? YouOtherAdd Family Member/PetYou must be logged in to add additional members to the order. Don't have an account? or Add Family Member/PetSign inTo continue, please enter your email address and password that you use for your account. | ||||||
| Select product strength & quantity:
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General Medication Fact Sheet for Wellbutrin
| Field | Information |
|---|---|
| Medication Name | Wellbutrin |
| Generic Name | Bupropion |
| Boxed/Label Warning | Increased risk of suicidal thoughts and behavior in children, adolescents, and young adults with major depressive disorder and other psychiatric disorders. |
| Purpose | Antidepressant used to treat major depressive disorder (MDD) and seasonal affective disorder (SAD), and as an aid to smoking cessation. |
| Mechanism of Action | Norepinephrine-dopamine reuptake inhibitor (NDRI). It inhibits the reuptake of norepinephrine and dopamine, increasing their levels in the brain. |
| Dosage Forms | Oral tablets (immediate-release, sustained-release, extended-release) |
| Available Strengths | 75 mg, 100 mg (immediate-release); 100 mg, 150 mg, 200 mg (sustained-release); 150 mg, 300 mg, 450 mg (extended-release) |
| Dosage Frequency | Immediate-release: Typically three times a day. Sustained-release: Typically twice a day. Extended-release: Typically once daily. |
| Common Side Effects | Insomnia, dry mouth, nausea, constipation, headache, dizziness, sweating, anxiety, tremor. |
| Serious Side Effects | Seizures, increased blood pressure, manic episodes, psychotic symptoms, angle-closure glaucoma, allergic reactions. |
| Drug Interactions | MAO inhibitors, other antidepressants, antipsychotics, antiarrhythmics, beta-blockers, codeine, tramadol, tamoxifen, corticosteroids, levodopa, amantadine. |
| Important Notes | Avoid alcohol. Use caution when driving or operating machinery. Inform your doctor of all medical conditions and medications you are taking. Can cause false positive on urine drug screens. |
| Storage | Store at room temperature away from moisture and light. |
| Missed Dose | Take as soon as you remember, unless it is almost time for your next dose. Do not double the dose. If you are taking the extended-release version once daily and you miss a dose, skip the missed dose and take your next dose at the regular time. |
| Alternatives | Zoloft (sertraline), Prozac (fluoxetine), Lexapro (escitalopram), Effexor (venlafaxine) |
Wellbutrin Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Zoloft (sertraline) | Selective serotonin reuptake inhibitor (SSRI) | Commonly prescribed for depression and anxiety disorders. |
| Prozac (fluoxetine) | Selective serotonin reuptake inhibitor (SSRI) | Another SSRI used for depression, OCD, and other conditions. |
| Lexapro (escitalopram) | Selective serotonin reuptake inhibitor (SSRI) | SSRI often prescribed due to its tolerability. |
| Effexor (venlafaxine) | Serotonin-norepinephrine reuptake inhibitor (SNRI) | Affects both serotonin and norepinephrine levels in the brain. |
Wellbutrin Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Insomnia | Seizures |
| Dry mouth | Increased blood pressure |
| Nausea | Manic episodes |
| Constipation | Psychotic symptoms |
| Headache | Angle-closure glaucoma |
| Dizziness | Severe allergic reactions (rash, itching, swelling, difficulty breathing) |
| Sweating | Suicidal thoughts/behavior |
| Anxiety | Hallucinations |
| Tremor | Irregular heartbeat |
Wellbutrin Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Major Depressive Disorder (MDD) | 100 mg twice daily (immediate-release) or 150 mg once daily (extended-release) | 300 mg to 400 mg per day (immediate-release) or 300 mg to 450 mg once daily (extended-release) | Administer doses at least 8 hours apart. |
| Seasonal Affective Disorder (SAD) | 150 mg once daily (extended-release) | 150 mg to 300 mg once daily (extended-release) | Begin treatment in the autumn before symptoms are expected. |
| Smoking Cessation | 150 mg once daily (extended-release) | 150 mg twice daily (extended-release) | Start treatment 1-2 weeks before quitting smoking. |
