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General Medication Fact Sheet for Xadago
| Field | Information |
|---|---|
| Medication Name | Xadago |
| Generic Name | Safinamide |
| Purpose | Treatment of Parkinson’s disease as an add-on therapy to levodopa/carbidopa |
| Mechanism of Action | MAO-B inhibitor and a glutamate release modulator |
| Dosage Forms | Oral tablets |
| Available Strengths | 50 mg, 100 mg |
| Dosage Frequency | Once daily |
| Common Side Effects | Dyskinesia, nausea, insomnia, dizziness, constipation |
| Serious Side Effects | Hypertension, hallucinations, impulse control disorders, serotonin syndrome |
| Drug Interactions | MAO inhibitors, antidepressants (SSRIs, SNRIs, TCAs), opioid medications, St. John’s Wort |
| Important Notes | Monitor blood pressure regularly; avoid tyramine-rich foods; report any new or worsening mental/mood changes |
| Storage | Store at room temperature away from moisture and light |
| Missed Dose | Take as soon as you remember; skip if it’s almost time for your next dose. Do not double the dose. |
| Alternatives | Rasagiline, Selegiline, Amantadine, Entacapone |
Xadago Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Rasagiline (Azilect) | Selective MAO-B inhibitor | Used as monotherapy in early Parkinson’s disease or as an add-on to levodopa. |
| Selegiline (Eldepryl) | Selective MAO-B inhibitor | Available in oral and transdermal forms; may have stimulant effects. |
| Amantadine (Gocovri) | NMDA receptor antagonist; increases dopamine release | May help reduce dyskinesia associated with levodopa. |
| Entacapone (Comtan) | COMT inhibitor | Used in combination with levodopa to prolong its effects. |
Xadago Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Dyskinesia | Hypertension |
| Nausea | Hallucinations |
| Insomnia | Impulse control disorders (e.g., compulsive gambling, hypersexuality) |
| Dizziness | Serotonin Syndrome |
| Constipation | Worsening of Parkinson’s symptoms |
Xadago Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Parkinson’s Disease (adjunct to levodopa) | 50 mg once daily | 100 mg once daily (may be increased after 2 weeks based on individual response) | Take once daily. May be taken with or without food. |
Xadago Price With And Without Insurance
| Purchase Context | Estimated Price |
|---|---|
| With Insurance | $15 |
| Without Insurance (U.S.) | $1300 |
| From CPS | $150 |
