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General Medication Fact Sheet for Xatral
| Field | Information |
|---|---|
| Medication Name | Xatral |
| Generic Name | Alfuzosin |
| Purpose | Treats symptoms of benign prostatic hyperplasia (BPH), or enlarged prostate, which includes difficulty urinating (hesitation, weak stream, incomplete emptying), painful urination, and frequent or urgent urination. |
| Mechanism of Action | Selective alpha-1 adrenergic receptor antagonist. Relaxes muscles in the prostate and bladder neck, making it easier to urinate. |
| Dosage Forms | Extended-release oral tablets |
| Available Strengths | 10 mg |
| Dosage Frequency | Typically once daily, after the same meal each day. |
| Common Side Effects | Dizziness, fatigue, headache, nasal congestion. |
| Serious Side Effects | Orthostatic hypotension (sudden drop in blood pressure upon standing), priapism (prolonged erection), severe allergic reaction. |
| Drug Interactions | Other alpha-blockers (e.g., Terazosin, Doxazosin), phosphodiesterase-5 (PDE5) inhibitors (e.g., sildenafil, tadalafil), certain antifungal medications (e.g., ketoconazole, itraconazole), some HIV protease inhibitors (e.g. ritonavir). |
| Important Notes | Take after the same meal each day. Avoid driving or operating machinery until you know how this medication affects you. Change positions slowly to minimize dizziness. Inform your doctor about all medications you are taking. |
| Storage | Store at room temperature away from moisture and light. |
| Missed Dose | If you miss a dose, take it as soon as you remember, unless it’s almost time for your next dose. Do not double the dose to catch up. |
| Alternatives | Tamsulosin (Flomax), Terazosin, Doxazosin, Finasteride (Proscar), Dutasteride (Avodart) |
Xatral Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Tamsulosin (Flomax) | Selective alpha-1A adrenergic receptor antagonist | Similar mechanism of action to alfuzosin; may have a slightly different side effect profile. |
| Terazosin | Non-selective alpha-1 adrenergic receptor antagonist | May require dose titration due to a higher risk of orthostatic hypotension. |
| Doxazosin | Non-selective alpha-1 adrenergic receptor antagonist | Similar to Terazosin, may require dose titration. |
| Finasteride (Proscar) | 5-alpha reductase inhibitor | Reduces the size of the prostate by blocking the conversion of testosterone to dihydrotestosterone (DHT). |
| Dutasteride (Avodart) | 5-alpha reductase inhibitor | Similar to finasteride but inhibits both type I and type II 5-alpha reductase isoenzymes. |
Xatral Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Dizziness | Orthostatic hypotension (sudden drop in blood pressure upon standing) |
| Fatigue | Priapism (prolonged erection) |
| Headache | Severe allergic reaction (rash, itching, swelling, difficulty breathing) |
| Nasal congestion | Fainting |
| Upper respiratory tract infection | Chest pain |
Xatral Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Benign Prostatic Hyperplasia (BPH) | 10 mg | 10 mg once daily | Take after the same meal each day. Swallow the tablet whole; do not crush or chew. |
