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General Medication Fact Sheet for Xcopri
| Field | Information |
|---|---|
| Medication Name | Xcopri |
| Generic Name | Cenobamate |
| Boxed/Label Warning | Potential for Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) |
| Purpose | Antiepileptic medication used to treat partial-onset seizures. |
| Mechanism of Action | Exact mechanism is not fully understood, but believed to involve enhancing inhibitory currents through GABA-A receptors and reducing excitatory currents. |
| Dosage Forms | Oral tablets |
| Available Strengths | 12.5 mg, 25 mg, 50 mg, 100 mg, 150 mg, 200 mg |
| Dosage Frequency | Once daily |
| Common Side Effects | Somnolence, dizziness, fatigue, diplopia (double vision), headache. |
| Serious Side Effects | Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS), QT shortening, suicidal thoughts or behavior, neurological adverse reactions. |
| Drug Interactions | CYP3A4 inducers (e.g., rifampin), CYP2C19 inhibitors or inducers, other antiepileptic drugs. |
| Important Notes | Must be titrated slowly to minimize side effects. Monitor for hypersensitivity reactions and suicidal thoughts. Women of childbearing potential should discuss contraception with their doctor. |
| Storage | Store at room temperature away from moisture and light. |
| Missed Dose | Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose. |
| Alternatives | Lamotrigine (Lamictal), Levetiracetam (Keppra), Topiramate (Topamax), Brivaracetam (Briviact) |
Xcopri Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Lamotrigine (Lamictal) | Blocks voltage-sensitive sodium channels. | Commonly used for various seizure types. Requires slow titration to avoid rash. |
| Levetiracetam (Keppra) | Binds to synaptic vesicle protein SV2A. | Generally well-tolerated, but can cause behavioral changes in some individuals. |
| Topiramate (Topamax) | Blocks sodium channels, enhances GABA activity, and antagonizes glutamate. | Can cause weight loss and cognitive side effects. |
| Brivaracetam (Briviact) | Binds to synaptic vesicle protein SV2A with higher affinity than Levetiracetam. | Similar to Levetiracetam, but may have fewer behavioral side effects. |
Xcopri Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Somnolence (drowsiness) | Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) |
| Dizziness | QT shortening |
| Fatigue | Suicidal thoughts or behavior |
| Diplopia (double vision) | Neurological adverse reactions (e.g., ataxia, gait disturbance) |
| Headache | Visual field defect |
Xcopri Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Partial-Onset Seizures | 12.5 mg once daily | Target maintenance dose typically 200 mg once daily, but can range from 100 mg to 400 mg once daily. | Titrate slowly, increasing by 12.5 mg every 2 weeks, then larger increments as tolerated, as directed by a physician. Take at the same time each day. |
Xcopri Price With And Without Insurance
| Purchase Context | Estimated Price |
|---|---|
| With Insurance | $600 – $1000 |
| Without Insurance (U.S.) | $1200 – $1645 |
| From Canada | $900 |
