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Xeloda (Capecitabine)
| Capecitabine (Generic) Capecitabine | ||||||
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Shipped from Canada | ||||||
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| Select product strength & quantity:
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General Medication Fact Sheet for Xeloda
| Field | Information |
|---|---|
| Medication Name | Xeloda |
| Generic Name | Capecitabine |
| Boxed/Label Warning | Patients receiving fluoropyrimidines, such as capecitabine, should be monitored frequently for evidence of hematologic, gastrointestinal, dermatologic, and neurologic toxicities. Therapy should be interrupted or discontinued if clinically significant toxicities occur. |
| Purpose | Treatment of certain types of cancer, including breast cancer and colorectal cancer. |
| Mechanism of Action | Capecitabine is a prodrug that is converted to Fluorouracil (5-FU) in the body, which inhibits DNA synthesis and slows the growth of cancer cells. |
| Dosage Forms | Oral tablets |
| Available Strengths | 150 mg, 500 mg |
| Dosage Frequency | Typically twice daily for a specified period, followed by a rest period, or as directed by a healthcare provider. |
| Common Side Effects | Diarrhea, nausea, vomiting, stomatitis (mouth sores), hand-foot syndrome (palmar-plantar erythrodysesthesia), fatigue, abdominal pain. |
| Serious Side Effects | Severe diarrhea, severe vomiting, severe stomatitis, severe hand-foot syndrome, myelosuppression (decreased blood cell counts), cardiotoxicity (heart problems), liver problems. |
| Drug Interactions | Warfarin and other coumarin-derivative anticoagulants, phenytoin, leucovorin, other chemotherapy drugs. |
| Important Notes | Take with food to reduce gastrointestinal side effects. Report any signs of severe side effects to your doctor immediately. Avoid antacids containing magnesium or aluminum during treatment. |
| Storage | Store at room temperature away from moisture and light. |
| Missed Dose | Take the missed dose as soon as you remember, unless it is almost time for your next scheduled dose. Do not double the dose. Consult your doctor. |
| Alternatives | Fluorouracil (5-FU), Oxaliplatin, Irinotecan, Trifluridine/Tipiracil (Lonsurf). |
Xeloda Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Fluorouracil (5-FU) | Inhibits DNA synthesis | Another fluoropyrimidine antimetabolite. Often used in combination with other drugs. |
| Oxaliplatin | Platinum-based antineoplastic agent that inhibits DNA replication | Used in combination with Fluorouracil and leucovorin for colorectal cancer. |
| Irinotecan | Inhibits topoisomerase I, leading to DNA damage | Used for colorectal cancer. |
| Trifluridine/Tipiracil (Lonsurf) | Thymidine-based nucleoside analog/Thymidine phosphorylase inhibitor | Used for metastatic colorectal cancer after failure of other therapies. |
Xeloda Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Diarrhea | Severe diarrhea (dehydration, electrolyte imbalance) |
| Nausea | Severe vomiting |
| Vomiting | Severe stomatitis (mouth sores) |
| Stomatitis (mouth sores) | Severe hand-foot syndrome (palmar-plantar erythrodysesthesia) |
| Hand-foot syndrome | Myelosuppression (decreased blood cell counts) |
| Fatigue | Cardiotoxicity (heart problems) |
| Abdominal pain | Liver problems |
Xeloda Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Metastatic Breast Cancer | Dose varies depending on body surface area and regimen. | Dose varies depending on body surface area and regimen. | Take with food. Dosage is based on individual treatment plans and may require adjustments. |
| Adjuvant Colon Cancer | Dose varies depending on body surface area and regimen. | Dose varies depending on body surface area and regimen. | Take with food. Dosage is based on individual treatment plans and may require adjustments. |
| Metastatic Colorectal Cancer | Dose varies depending on body surface area and regimen. | Dose varies depending on body surface area and regimen. | Take with food. Dosage is based on individual treatment plans and may require adjustments. |
Xeloda Price With And Without Insurance
| Purchase Context | Estimated Price |
|---|---|
| With Insurance | $225 – $425 |
| Without Insurance (U.S.) | $2000 – $2500 |
| From CPS | $520 |
