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Xifaxan (Rifaximin)
| Rifaximin (Generic) Rifaximin | ||||||
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Shipped from Mauritius | ||||||
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| Select product strength & quantity:
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| Rifaxitab (Generic) Rifaximin | ||||||
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Shipped from Mauritius | ||||||
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| Sibofix-550 (Generic) Rifaximin | ||||||
Shipped from Singapore | ||||||
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Who is the product for? YouOtherAdd Family Member/PetYou must be logged in to add additional members to the order. Don't have an account? or Add Family Member/PetSign inTo continue, please enter your email address and password that you use for your account. | ||||||
General Medication Fact Sheet for Xifaxan
| Field | Information |
|---|---|
| Medication Name | Xifaxan |
| Generic Name | Rifaximin |
| Purpose | Treatment of travelers’ diarrhea caused by noninvasive strains of *E. coli*, hepatic encephalopathy, and irritable bowel syndrome with diarrhea (IBS-D). |
| Mechanism of Action | Inhibits bacterial RNA synthesis by binding to bacterial DNA-dependent RNA polymerase. |
| Dosage Forms | Oral tablets |
| Available Strengths | 200 mg, 550 mg |
| Dosage Frequency | Depends on the condition being treated; typically two to three times daily. |
| Common Side Effects | Nausea, headache, dizziness, fatigue, abdominal pain. |
| Serious Side Effects | *C. difficile*-associated diarrhea (CDAD), severe allergic reactions (rare). |
| Drug Interactions | P-glycoprotein (P-gp) inhibitors may increase rifaximin exposure. |
| Important Notes | Not effective against systemic bacterial infections. Use with caution in patients with severe hepatic impairment. |
| Storage | Store at room temperature away from moisture and light. |
| Missed Dose | Take as soon as you remember; skip if it’s almost time for your next dose. Do not double the dose. |
| Alternatives | Loperamide, Bismuth subsalicylate, Eluxadoline, Alosetron |
Xifaxan Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Loperamide (Imodium) | Opioid receptor agonist; slows intestinal motility. | Used for symptomatic relief of diarrhea. Does not treat underlying infection. |
| Bismuth subsalicylate (Pepto-Bismol) | Antisecretory and antimicrobial effects. | Used for symptomatic relief of diarrhea. |
| Eluxadoline (Viberzi) | Mu-opioid receptor agonist, delta-opioid receptor antagonist, and kappa-opioid receptor agonist. | Used for IBS-D; controlled substance. |
| Alosetron (Lotronex) | 5-HT3 receptor antagonist. | Used for severe IBS-D in women; restricted use due to potential side effects. |
Xifaxan Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Nausea | *C. difficile*-associated diarrhea (CDAD) |
| Headache | Severe allergic reactions (rash, itching, swelling, difficulty breathing) |
| Dizziness | Liver enzyme elevations |
Xifaxan Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Travelers’ Diarrhea | 200 mg | 200 mg three times daily for 3 days | Take with or without food. |
| Hepatic Encephalopathy | 550 mg | 550 mg twice daily | Take with or without food. |
| IBS-D | 550 mg | 550 mg three times daily for 14 days | Take with or without food. May be repeated if symptoms recur. |
Xifaxan Price With And Without Insurance
| Purchase Context | Estimated Price |
|---|---|
| With Insurance | $0 – $500 |
| Without Insurance (U.S.) | $1500 – $2000 |
| From CPS | $50 |
